Examining the role of venues in structuring sexual and drug-use networks among MS

描述（由申请人提供）：经验和建模研究都支持性网络结构在性传播感染（STI）（如人类免疫缺陷病毒1型（HIV-1））的传播动力学中起核心作用的观点。在男男性行为者中，酒吧和俱乐部等场所不仅可以形成这些性网络，还可以形成非法药物使用网络，特别是所谓的“俱乐部药物”。由于“俱乐部毒品”，特别是甲基苯丙胺的使用与艾滋病毒风险行为的增加有关，因此必须了解俱乐部毒品使用与男男性行为者性网络的交叉点。该提案旨在开发模型，以梳理艾滋病毒风险行为，非法药物使用及其相互作用中的个人与场所水平因素。首先，我们将调整统计模型，以前用于研究邻里效应对健康的影响，以个人酒吧和俱乐部的规模，以描述非法药物使用和艾滋病毒的危险行为的空间分布。这些模型将应用于对男男性行为者非注射吸毒和艾滋病毒风险行为进行时间-地点抽样研究的试点数据。其次，我们将开发一个基于场所的HIV危险行为和药物使用的动态网络模型。这些模型将使我们能够评估场所在构建艾滋病毒风险和药物使用网络中所发挥的作用，以及针对环境层面的风险行为和药物使用的行为干预措施可能产生的影响。该提案将帮助首席研究员过渡到成为艾滋病毒和药物使用领域的独立研究人员，同时利用他目前的技能。 公共卫生相关性：在男男性行为者中，酒吧和俱乐部等场所可以形成性网络和非法药物使用网络，特别是所谓的“俱乐部药物”网络。我们将使用统计模型来描述非法药物使用和艾滋病毒风险行为的空间分布，并开发一个基于场所的艾滋病毒风险行为和药物使用的动态网络模型，该模型将使用基于社会网络的方法进行参数化。这些模型将使我们能够评估场所在构建艾滋病毒风险和药物使用网络中所发挥的作用，以及针对环境层面的风险行为和药物使用的行为干预措施可能产生的影响。

DESCRIPTION (provided by applicant): Both empirical and modeling studies support the notion that sexual network structure plays a central role in transmission dynamics of sexually transmitted infections (STIs) such as human immunodeficiency virus type 1 (HIV-1). Among men who have sex with men (MSM), venues such as bars and clubs can not only shape these sexual networks, but also shape networks of illicit drug use, especially of so-called `club drugs'. As the use of `club drugs', especially methamphetamine, has been associated with increased levels of HIV risk behaviors, it is important to understand the intersection of club drug use and sexual networks among MSM. This proposal seeks to develop models to tease apart individual- versus venue-level factors in HIV risk behaviors, illicit drug use, and their interaction. Firstly, we will adapt statistical models previously used to study the impact of neighborhood effects on health to the scale of individual bars and clubs in order to describe the spatial distribution of illicit drug use and HIV risk behaviors. These models will be applied to pilot data from a time-location sampling study of non-injection drug use and HIV risk behaviors among men who have sex with men. Secondly, we will develop a dynamic venue-based network model of HIV risk behavior and drug use. These models will allow us to assess the role that venues play in structuring HIV risk and drug use networks, and the possible impact of behavioral interventions targeted at risk behaviors and drug use at the environmental level. This proposal will help the Principal Investigator transition to being an independent researcher in the area of HIV and drug use, while exploiting his current skill set. PUBLIC HEALTH RELEVANCE: Among men who have sex with men (MSM), venues such as bars and clubs can shape both sexual networks and networks of illicit drug use, especially of so-called `club drugs'. We will use statistical models to describe the spatial distribution of illicit drug use and HIV risk behaviors, and develop a dynamic venue-based network model of HIV risk behavior and drug use, which will be parameterized using social network based methods. These models will allow us to assess the role that venues play in structuring HIV risk and drug use networks, and the possible impact of behavioral interventions targeted at risk behaviors and drug use at the environmental level.