Error-Related Brain Activity and Risk for Anxiety and Depressive Disorders

描述(申请人提供)：错误相关负波(ERN)是在头皮观察到的一种皮层反应，在错误反应后约50ms最大。许多研究已经报道了焦虑和抑郁参与者的ERN增加，最近，在焦虑症的儿科患者中也报告了类似的结果，无论是在成功的治疗之前还是之后。其他研究报告称，在那些报告了高度负面情绪性和惩罚敏感性的受试者中，与错误相关的大脑活动增加，这些人格特征在焦虑症和抑郁症中都会升高。总而言之，这些结果表明，ERN的增加可能反映了自我监控过程中的信息处理异常，这反映了焦虑和抑郁障碍的共同风险因素。为了解决这种可能性，本研究将研究ERN与两个与焦虑和抑郁障碍的发展相关的众所周知的危险因素：家族性精神病理学以及消极情绪性和行为抑制的气质测量。本研究的总体目标是评估错误相关的大脑活动与焦虑和抑郁的发展之间的关系，并评估错误相关的大脑活动作为情感性精神病理学的潜在内表型的实用性。此外，本研究还将有助于关于个体气质和个性差异的发育神经生物学的文献。公共卫生相关性：这项研究探索了300名6岁儿童样本中与错误相关的大脑活动与父母的精神病理学以及行为抑制和负面情绪的实验室测量之间的关系。这项研究旨在检查错误相关大脑活动的变化是否与这些众所周知的导致焦虑和抑郁障碍的危险因素有关。

DESCRIPTION (provided by applicant): The error-related negativity (ERN) is an electrocortical response observed at the scalp that is maximal approximately 50 ms after an erroneous response. A number of studies have reported increased ERNs in anxious and depressed participants, and recently, a similar pattern of results has been reported in anxious pediatric patients both before and after successful therapy. Other studies have reported increased error- related brain activity in subjects who report high levels of negative emotionality and punishment sensitivity personality traits that are elevated across both anxiety disorders and depression. Collectively, these results suggest that an increased ERN may reflect information-processing abnormalities during self-monitoring that reflect a shared risk factor for anxiety and depressive disorders. To address this possibility, the present study will examine the ERN in relation to two well-known risk factors related to the development of anxiety and depressive disorders: familial psychopathology and temperamental measures of negative emotionality and behavioral inhibition. The overall goal of this study is to evaluate the relationship between error-related brain activity and the development of anxiety and depression, and to assess the utility of error-related brain activity as a potential endophenotype for affective psychopathologies. Additionally, the present study will contribute to the literature on the developmental neurobiology of individual differences in temperament and personality. PUBLIC HEALTH RELEVANCE: This study explores the relationship between error-related brain activity, and parental psychopathology and laboratory measures of behavioral inhibition and negative emotionality in a sample of 300 6-year olds. The present study aims to examine whether variation in error- related brain activity relates to these well-known risk factors for developing both anxiety and depressive disorders.