Early Alcohol Use Onset: Influence of Religion-Spirituality Dimensions

描述（由申请人提供）：目的：增加对酒精使用的调节影响的认识，特别是宗教-精神（R/S）维度和潜在的遗传和环境影响对酒精发生和发展的R/S调节。在当前病原学模型的指导下，分析还将检查R/S对酒精使用障碍遗传风险的假设介质的影响：行为控制不足和负面影响调节。目的：(1)表征R/S维度与R/S-酒精使用关联；(2)利用全表型模型，表征R/S维度对早发性和重度酒精使用的主要和交互影响；(3)估计遗传、共享和非共享环境对R/S维度方差和协方差的贡献，以及它们与酒精使用年龄和酒精使用程度的相关性；(4)检验R/S维度在调节基因或共同环境对酒精使用年龄和酒精使用程度的影响中的作用，并表征调节（基因型x环境）效应。方法：二级数据分析将对密苏里州出生的青春期女性双胞胎及其家庭的物质使用开始和进展以及相关精神疾病的大规模前瞻性研究中现有的未识别数据进行分析。可用的R/S变量将允许在酒精中毒病因学的两个关键模型中检查五个R/S维度的调节作用。相关性：由此产生的研究结果对于(a)描述酒精中毒风险中介和调节因子的病因学研究，以及(b)经常观察到治疗增强和保护R/S对酒精中毒结果的治疗和预防工作将具有相当重要的意义。

DESCRIPTION (provided by applicant): Objective: To increase knowledge of moderating influences on alcohol use, specifically, religious-spiritual (R/S) dimensions and underlying genetic and environmental effects on R/S moderation of alcohol onset and progression. Guided by current etiological models, analyses will also examine R/S effects on the hypothesized mediators of genetic risk for alcohol use disorders: behavioral undercontrol and negative affect regulation. Aims: (1) characterization of R/S dimensionality and R/S-alcohol use association; (2) characterization, using full phenotypic models, of main and interactive effects of R/S dimensions on early onset and heavy alcohol use; (3) estimation of genetic, shared, and non-shared environmental contributions to the variance and covariance of R/S dimensions and to their correlations with age-at-onset of alcohol use and heaviness of alcohol use; (4) to test the role of R/S dimensions in moderating genetic or shared environmental effects on age-at-onset of alcohol use and heaviness of alcohol use, and to characterize moderating (genotype x environment) effects. Method: Secondary data analyses will be conducted on existing, deidentified data from a large-scale prospective research study of substance use onset and progression and associated psychiatric disorders from previous assessments of Missouri-born adolescent female twins and their families. Available R/S variables will permit examination of the moderating effects of five R/S dimensions within two key models of alcoholism etiology. Relevance: Resultant findings will be of considerable importance to (a) etiological efforts in characterizing the mediators and moderators of alcoholism risk, and to (b) treatment and prevention efforts that have frequently observed treatment enhancing and protective effects of R/S on alcoholism outcomes.