Imaging Core

成像核心的总体目标是开发、实施、优化和验证定量 肿瘤治疗反应的替代生物标志物。该核心将致力于提供科学的 和技术资源，并支持小动物体内癌症模型的非侵入性成像] 并且是本申请中描述的四个项目中的三个项目成功的基础。项目 由成像核心支持的是针对采用现有的以及新的，靶向治疗 这将引出可以通过光学、SPECT和PET方法成像的分子特征， 然后用从超声，MRI， 和CT。特别是，项目1（PI：Arteaga）和项目3（PI：Pietenpol）将采用非侵入性 分子成像指标（FLT-PET、FDG-PET、Annexin-V microSPECT和光学），以评估 肿瘤细胞增殖、葡萄糖代谢和细胞凋亡。计划2 (PI：Mundy）将采用非侵入性分子成像指标（生物发光，荧光， microSPECT/CT）来追踪乳腺癌骨转移并评估骨质量。除了 提供SPORE项目所需的方法，成像核心将开发技术， 可以加强这些研究，并支持发展试点项目。的设备和 支持SPORE内研究者研究所需的人员将由 小动物成像中心（CSAI）（请参阅参考资料）。通过SPORE获得的资金将 支持与专家成像科学学院的合作，以开发和实施 最先进的成像协议;为成像系统操作员和技术人员提供支持， 处理动物准备和监测以及操作仪器;数据支持 分析和定量图像分析定制的特定应用，包括配准 以及多种成像模式、组织学和蛋白质组学的整合。 1.提供肿瘤发生、进展和治疗反应的非侵入性成像指标， 范德比尔特乳房孢子的研究人员。 2.提供与专家成像科学学院的合作，以实施切割 边缘成像协议，以解决每个研究者的目标。成像核心将支持 核、光学、MRI、CT和超声成像方面的专家。 3.为数据分析和定量图像分析提供支持， 应用，包括多种成像模式的配准和集成， 组织学和蛋白质组学。

The overall goal of the Imaging Core is to develop, implement, optimize, and validate quantitative surrogate biomarkers of tumor treatment response. This Core will be dedicated to providing scientific and technical resources and support for non-invasive imaging of small animal models of cancer in vivo] and is fundamental to the success of three of the four projects described in this application. Projects supported by the Imaging Core are directed at employing existing as well as novel, targeted therapies which will elicit molecular signatures that can be imaged via optical, SPECT, and PET methods and then complemented with the (downstream) physiological information obtained from ultrasound, MRI, and CT. In particular, Project 1 (PI: Arteaga) and Project 3 (PI: Pietenpol) will employ noninvasive molecular imaging metrics (FLT-PET, FDG-PET, Annexin-V microSPECT and optical) to assess tumor cell proliferation, glucose metabolism, and apoptosis in response to novel therapies. Project 2 (PI: Mundy) will employ noninvasive molecular imaging metrics (bioluminescence, fluorescence, and microSPECT/CT) to track breast cancer metastases to bone and assess bone quality. In addition to providing the methods required by SPORE projects, the Imaging Core will develop techniques that can augment these studies as well as support developmental pilot projects. The equipment and personnel needed to support research by investigators from within the SPORE will be provided by the Center for Small Animal Imaging (CSAI) (see Resources)). Funds obtained through the SPORE will support collaborations with expert imaging science faculty for the development and implementation of cutting edge imaging protocols; support for imaging system operators and technical staff who will handle animal preparation and monitoring as well as operate the instruments; support for data analysis and for quantitative image analysis customized to specific applications, including the coregistration and integration of multiple imaging modalities, histology and proteomics. 1. Provide non-invasive imaging metrics of tumor initiation, progression and treatment response to investigators in the Vanderbilt Breast SPORE. 2. Provide collaborations with expert imaging science faculty for the implementation of cutting edge imaging protocols to address each investigators goals. The Imaging Core will support experts in nuclear, optical, MRI, CT, and ultrasound imaging. 3. Provide support for data analysis and for quantitative image analysis customized to specific applications, including the co-registration and integration of multiple imaging modalities, histology and proteomics.