Animal Models and Pathology

埃默里大学分子生物学和病理学专业资源（核心D） 翻译成像中心（EMTIC）将通过在两个关键领域提供服务， 领域：动物模型和组织病理学服务。核心是成功的必要条件， EMTIC是高度综合性的，被所有四个研究项目和所有五个试点项目所利用。 动物模型组件将用于生成和表征用于分子生物学的新型啮齿动物模型。 成像在癌症研究中的应用，并将通过收集和分析肿瘤来协助个人项目。 这些动物的数据。癌症相关动物模型的产生和分析是癌症研究的核心。 EMTIC由于高度重视开发和验证新型示踪剂， 临床前研究，可用作肿瘤检测、进展和 体内传播。动物部分也将作为一个保存库， 可能用于研究项目的任何新型转基因小鼠品系的分布， 必要时开展试点项目。中心将进行尸检和组织采集， 实验动物，并将从选定的动物中收集肿瘤样品用于产生细胞系 供EMTIC调查人员使用。核心的病理学组件将提供组织和肿瘤 采购专业知识，组织处理，以及组织学和免疫组织化学分析， 来自人类疾病和动物模型的肿瘤样品。组织学和免疫组织化学 对来自患者和动物模型的肿瘤的评估将是必要的， 验证通过PET、MRI和光学方法用靶向生物标志物检测新型示踪剂 在组织中。 因此，动物模型和病理学核心将对本研究的总体目标做出重大贡献。 EMTIC从科学的角度提供这些服务以及专业知识。此外该 将这些服务纳入一个全面核心组成部分， 通过加强努力，避免不必要的实验重复， 并利用核心人员的集体专业知识。

The Animal Models and Pathology Specialized Resource (Core D) of the Emory Molecular and Translational Imaging Center (EMTIC) will assist the overall project by providing service in two critical areas: animal models and histopathologic services. The Core is necessary for the success of the EMTIC and is highly integrative, being utilized by all four research projects and all five pilot projects. The animal models component will act to generate and characterize novel rodent models for molecular imaging in cancer research and will assist the individual projects by collecting and analyzing tumor data from these animals. The production and analysis of relevant animal models of cancer is central to the EMTIC because of the heavy emphasis on the development and validation of novel tracers in preclinical studies that could be utilized as markers for tumor detection, progression, and dissemination in vivo. The animal component will also serve as a repository for the preservation and distribution of any novel transgenic strains of mice that may be utilized in the Research Projects and Pilot Projects as they become necessary. The Core will perform necropsy and tissue collection for experimental animals, and will collect tumor samples from selected animals for generation of cell lines for use by EMTIC investigators. The pathology component of the Core will provide tissue and tumor procurement expertise, tissue processing, as well as histological and immunohistochemical analysis of tumor samples from human disease and animal models. Histologic and immunohistochemical evaluation of tumors from patients and animal models will be necessary in order to correlate and validate the detection of novel tracers by PET, MRI and optical methods with the targeted biomarkers in tissues. Thus the Animal Models and Pathology Core will contribute significantly to the overall goals of the EMTIC from a scientific perspective by providing these services as well as expertise. In addition, the inclusion of these services into a comprehensive core component will provide additional benefit to EMTIC as a whole, through consolidation of effort, avoidance of unnecessary experimental duplication, and by drawing upon the collective expertise of the Core personnel.