Personality Disorder Over 20yrs: Risks, Course & Impact

描述(由申请人提供)：这项拟议的研究扩展了一项纵向研究，研究对象为自1975年以来接受研究的784人，评估时的平均年龄为38岁。该队列最初是随机抽样的，并一直密切代表着它所来自的年龄组和地理区域。独一无二的是，人格障碍(PD)从青春期早期就与轴I障碍以及广泛的风险和结果一起进行了评估。在《社区儿童研究》出版或出版的153份出版物中，有27份已证明PD与许多儿童风险有关，进而对随后的轴I障碍和严重的功能障碍构成独特的风险。拟议研究的目的是调查：成年后帕金森病症状和障碍的患病率和持续性的变化；既往和现在的帕金森病对成人功能、健康和保健的影响；轴心I障碍和帕金森病之间的预期关系；特定的基因差异与帕金森病及其相关功能的关系；帕金森病和帕金森病变化的环境和经验危险因素；风险/基因交互作用在预测帕金森病患病率和病程中的作用；父母帕金森病对父母和子女的影响。

DESCRIPTION (provided by applicant): The proposed study extends a longitudinal study of 784 persons who have been studied since 1975, and who will be an average age of 38 when assessed. The cohort was originally randomly sampled, and has remained closely representative of the age group and geographical area from which it was drawn. Uniquely, personality disorders (PDs) have been assessed since early adolescence, in conjunction with the Axis I disorders, and a broad range of risks and outcomes. In 27 publications (of 153 published or in press from the Children in the Community study) PDs have been shown to be related to a number of childhood risks and, in turn, to constitute unique risks for both subsequent Axis I disorders and for serious impairment in function. The aims of the proposed research are to investigate: Changes in the prevalence and persistence of PD symptoms and disorders in mid-adulthood; Impact of previous and current PD on adult function, health, and health care; Prospective relationships between Axis I disorders and PD; Relationship of specific genetic differences to PD and related functioning; Environmental and experiential risk factors for PD and PD change; Risk/ gene interaction in predicting prevalence and course of PD; Impact of parental PD on parenting and on offspring.