PARKINSON'S DISEASE NEUROPROTECTION CLINICAL TRIALS: CLINICAL CENTER

描述（申请人提供）：帕金森病（PD）是一种常见的进行性神经退行性疾病。最近的研究已经提出了一些潜在的神经保护剂，但需要进行大规模的临床试验来确定其有效性。这只能由经验丰富的PD试验中心组成的联盟来完成。该提案的目的是概述我们成为中心的经验，兴趣和兴奋，以及与其他站点合作的意愿。卡尔加里大学的运动障碍项目是阿尔伯塔省南部唯一的PD诊所，服务于近200万人口。其主要目的是为帕金森病（PD）患者提供与临床研究相结合的全面临床护理。临床医生和护士协调员在协作临床试验方面有12年的经验。该诊所在国际上享有盛誉，因为它一直是高招聘人员，并提供高质量的参与。其中一个优势是临床护理与临床研究在一个单位的整合。无论患者是否正在接受临床护理和/或参与临床试验，他们通常会长期由同一位神经科医生和护士协调员照顾。由于以下因素，招募拟议的试验将很容易实现：1)庞大的转诊基础2)该地区没有竞争的PD中心3)建立了包括3000名患者的数据库4)与社区和亚专科神经学家的合作关系5)与PD专业组织的密切合作关系，包括南阿尔伯塔帕金森学会和加拿大帕金森学会6)与卡尔加里大学和专业组织链接的诊所网站。对已确定的患者群体的维护通过已建立的项目的组织得到加强。1)证明患者对我们的综合护理计划的忠诚和赞赏2)临床研究和临床计划的整合3)神经科医生和临床护士的持续参与4)患者通过电子邮件和电话与诊所成员进行轻松和定期的沟通。该诊所得到了卡尔加里大学和卡尔加里卫生地区的大力支持，以实现其为PD患者提供全面，综合的最先进方案的目标，并推进该领域的研究。

DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a common, progressive, neurodegenerative disorder. Recent studies have suggested a number of potential neuroprotective agents, but a large clinical trial would be needed to determine effectiveness. This could only be accomplished by a consortium of experienced PD trial centers. The aim of this proposal is to outline our experience, interest and excitement in becoming a center, and willingness to cooperate with other sites. The Movement Disorders Program at the University of Calgary is the only PD clinic in Southern Alberta, serving a population of almost 2 million. Its major aim is to provide comprehensive clinical care integrated with clinical research to Parkinson's disease (PD) patients. Clinic physicians and nurse coordinators have a proven track record of 12 years of experience in collaborative clinical trials. The clinic has an international reputation for being consistently a high recruiter, and for providing high quality participation. One of the strengths is the integration of clinical care with clinical research in one unit. Patients will frequently be cared for by the same neurologist and nurse coordinator on a long-term basis, whether they are receiving clinical care and/or participating in clinical trials. Recruitment for the proposed trials will be easily achieved due to the following factors: 1) large referral base 2) no competing PD centres in the area 3) established database including 3000 patients 4) collegial working relationship with community and sub-specialty neurologists 5) close working relationship with PD lay organizations, including Parkinson's Society of Southern Alberta, and Parkinson Society Canada 6) clinic website linked to University of Calgary and lay organizations. Maintenance of the identified patient population is enhanced by the organization of the established program. 1) proven loyalty and appreciation of patients for our comprehensive care program 2) integration of clinical research and clinical programs 3) continuity of involvement of neurologists and nurse clinicians 4) ease and regularity of patient communication with clinic members via e-mail and phone. The clinic has strong support from the University of Calgary and Calgary Health Region to fulfill its aim of providing comprehensive, integrated state of the art programs to PD patients, and advancing research in this area.