CORE 2 DB5: PROTEOLYTIC PATHWAYS IN ACUTE VASCULAR RESPONSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 驱动生物学项目5：急性血管反应中的蛋白质分解途径。 维持血管网络对所有哺乳动物来说都是至关重要的。我们将检验这一假设 依赖蛋白水解酶的翻译后通路调节血管的维持(内稳态) 网络。血管网络的主要组成部分是血管内皮细胞，血管光滑 肌肉细胞(VSMCs或壁细胞)和细胞外基质(ECM)分子。在……下面 动态平衡条件下，网络被维持在静止状态；然而，在生理或 病理刺激下，先天程序迅速失活/激活，促进血管重塑。 这些事件的一个后果是血管扩张，随后血浆蛋白泄漏到 间质。我们计划研究与这种急性血管反应有关的蛋白分解途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 5: Proteolytic Pathways in Acute Vascular Response . Maintenance of vascular network is crucial to all mammals. We will test the hypothesis that protease-dependent post-translational pathways regulate the maintenance (homeostasis) of vascular networks. The major components of the vasular network are endothelial cells, vascular smooth muscle cells (VSMCs or mural cells) and extracellular matrix (ECM) molecules. Under homeostatic conditions, networks are maintained in a quiescent state; however, following physiologic or pathologic stimulation, innate programs are rapidly inactivated/activated fostering vascular remodeling. One consequence of these events is vasodilation, and subsequent leakage of plasma proteins into interstitium. We plan to investigate the proteolytic pathways involved in this acute vascular response