The Pathology/Histology Core

病理核心，将为中央资助金的所有6个项目提供组织病理学服务。这个 服务将包括常规的石蜡切片和冰冻的主动脉切片的制备和组织化学 免疫组织化学染色，并对主动脉组织切片进行明场、荧光和 共聚焦显微镜。病理核心还帮助每个项目进行形态测量分析和 组织病理学标本制备。与其他核心合作，将收集患者的样本， 固定在福尔马林中，存入银行，或在每个项目中以其他方式说明。形态和免疫组织化学 具有针对血管细胞和炎症标志物的抗体以及特定的基因产品 将继续执行每个项目确定的项目。每个项目都将提供一份报告和 相关调查结果的照片记录。

Pathology Core, will provide histopathology services to all 6 projects in the Central Grant. The services will include routine preparation and histochemistry of paraffin and frozen aortic sections, regular immunostaining, and morphological analysis of the aortic tissue sections by bright field, fluorescence, and confocal microscopy. The Pathology Core also helps each project for morphometry analysis and histopathological sample preparation. In collaboration with other cores, patient's samples will be collected, fixed in formalin, banked, or otherwise stated in each project. Morophological and immunohistochemistry with antibodies against markers for vascular cells and inflammation as well as particular gene products identified by each project will be pursued. Each project will be supplied with a report and photodocumentation of relevant finding.