Musculoskeletal Repair and Regeneration

描述（由申请人提供）： 特殊外科医院（HSS）肌肉骨骼核心中心的主题是“肌肉骨骼修复和再生”。肌肉骨骼修复和再生研究的进步需要临床医生，生物学家，化学家和工程师的协调努力。HSS核心中心通过提供设施和基础设施来支持这一目标，在这些设施和基础设施中，思想和资源的共享增强了当前核心研究人员的互动，并提供激励措施，以吸引更多的研究人员加入我们现有的16个成员多学科研究基地。该研究基地的成员正在研究与健康和疾病中骨和软骨的发育和修复相关的科学问题，以实现“功能性组织工程”的最终目标。为了实现这些研究者的目标，核心中心通过行政部门就研究设计和资助、通过丰富计划进行培训和审查、通过试点和可行性（P&F）计划招募新研究者以及通过内部数据库进行数据共享提供建议。有三个研究核心与核心中心的主题相关的广泛的专业知识。 分析显微镜核心提供环境扫描电子显微镜，透射电子显微镜，细胞外和细胞内表征的专业知识，以及样品制备。成像核心提供了独特的访问振动光谱成像（红外和拉曼），在体内分子成像，离体微型计算机断层扫描的创新技术。机械和材料评估核心提供了独特的工具，用于测量组织和其他复合材料的机械性能和特性，并通过共享HSS和Cornell Ithaca Sibley工程学院的资源来进行材料表征。这些地点之间通过每周举行电视会议保持密切关系。初步拟议资助期的试点和可行性计划正在研究小鼠模型，这些模型提供了对骨和软骨的细胞、组织和功能工程方面的见解。该计划已经使我们能够吸引新的研究人员到肌肉骨骼修复和再生领域，我们预计核心中心将使我们能够继续发展这些相互作用。

DESCRIPTION (provided by applicant): The theme of the Musculoskeletal Core Center at the Hospital for Special Surgery (HSS) is "Musculoskeletal Repair and Regeneration". The advancement of research in Musculoskeletal Repair and Regeneration requires the coordinated efforts of clinicians, biologists, chemists, and engineers. The HSS Core Center supports this goal by providing facilities and an infrastructure in which sharing of ideas and resources enhances interactions of current Core investigators and provides incentives to attract additional investigators to our existing 16 member multidisciplinary Research Base. Members of the research base are investigating scientific questions related to the development and repair of bone and cartilage in health and disease, towards the ultimate goal of "functional tissue engineering". To achieve the goals of these investigators, the Core Center, through the Administrative Unit, provides advice on study design and grantsmanship, training and review through an Enrichment Program, recruitment of new investigators via a Pilot and Feasibility (P&F) program, and Data Sharing through an in-house data base. There are three Research Cores with extensive expertise related to the theme of the Core Center. Analytical Microscopy Core provides access to an Environmental Scanning Electron Microscope, a Transmission Electron Microscope, expertise in extracellular and intracellular characterization, and specimen preparation. Imaging Core provides unique access to the innovative techniques of Vibrational Spectroscopic Imaging (Infrared and Raman), in vivo Molecular Imaging, and ex vivo micro-Computed Tomography. Mechanical and Material Assessment Core provides unique tools for measuring mechanical performance and properties of tissues and other composite materials and for material characterization by sharing resources of HSS and the Sibley School of Engineering at Cornell Ithaca. Close relations between these sites are maintained through weekly video-conferencing. The Pilot and Feasibility program for the initial proposed funding period is investigating mouse models that provide insight into cell, tissue, and functional engineering aspects of bone and cartilage. This program has already allowed us to attract a new investigator to the field of Musculoskeletal Repair and Regeneration, and we anticipate the Core Center will enable us to continue to grow these interactions.