Clinical Epidemiology and Health Services Research

华盛顿大学CFAR临床流行病学和卫生服务研究核心(CE&HSR)的目标(正式 卫生服务研究核心)是支持UW CFAR附属的临床和翻译艾滋病毒/艾滋病研究 研究人员通过提供艾滋病毒/艾滋病患者的纵向信息和临床专业知识 流行病学和卫生服务研究方法；并促进对问题的跨学科方法 通过促进临床医生研究人员、流行病学家、卫生部门 服务研究人员、生物统计学家、行为科学家和基础科学家。核心的一个主要目标是促进 HIV/AIDS临床研究在常规临床中检查HIV感染患者的长期结果 实践，包括抗逆转录病毒治疗的效果、共病情况和治疗的并发症。 该核心的其他目标是支持开展干预性研究并促进翻译 通过提供与在艾滋病毒感染人群中收集的样本相联系的临床患者数据进行研究。 在本供资周期的第五个年头开始时，CE和HSR核心已完成和 超过了我们在上次申请中提出的目标。UWHIS已扩展以捕获新数据 支持对关键艾滋病毒亚群的研究。该中心维持艾滋病毒感染患者的登记 愿意参与研究并支持研究人员准备拨款申请的组织 确定符合建议研究标准的注册患者，提供潜在研究对象列表 招募，并解决有关艾滋病毒/艾滋病患者的临床结果的问题。这个 CE&HSR Core为华盛顿大学艾滋病毒标本储存库提供支持，并与临床 支持新研究人员的研究、开发、生物识别和临床反病毒核心 获奖者、临床结果研究和转化研究。核心人员一直活跃在 国家和国际队列协作，如CFAR综合临床系统网络 (CNICs)和北美地区(IEDEA)项目，北美艾滋病队列 研究与设计合作(NA-ACCORD)。最后，正在使用核心资源来实施 促进收集新的以患者为基础的依从性、脂营养不良、 抑郁、HRQL和药物滥用。

The goals of the UW CFAR Clinical Epidemiology and Health Services Research Core (CE&HSR) (formally Health Services Research Core) are to support clinical and translational HIV/AIDS research by UW CFARaffiliated investigators by providing longitudinal HIV/AIDS patient information and expertise in clinical epidemiology and health services research methods; and to foster interdisciplinary approaches to questions concerning HIV/AIDS by facilitating collaborations between clinician researchers, epidemiologists, health services researchers, biostatisticians, behavioral, and basic scientists. A main goal of the Core is to promote clinical HIV/AIDS research examining the long-term outcomes of HIV-infected patients in routine clinical practice, including the effects of antiretroviral therapy, co-morbid conditions, and complications of treatment. Additional goals of the Core are to support the conduct of interventional studies and to facilitate translational research by supplying clinical patient data linked to specimens collected on the HIV-infected population. At the start of its fifth year of the current funding cycle, the CE&HSR Core has accomplished and exceeded the goals set forth in our last application. The UWHIS has been expanded to capture new data types to support research on key HIV subpopulations. The Core maintains a registry of HIV-infected patients who are willing to participate in research studies and supports researchers preparing grant applications by identifying registry patients who meet proposed study criteria, providing lists of potential study subjects for recruitment, and addressing questions concerning clinical outcomes for persons with HIV/AIDS. The CE&HSR Core provides support to the UW HIV Specimen Repository and collaborates with the Clinical Research, Developmental, Biometrics, and Clinical Retrovirology cores to support new investigator awardees, clinical outcomes research, and translational research. Core personnel have been active in national and international cohort collaborations such as the CFAR Network of Integrated Clinical Systems (CNICS) and the North American region of the (IEDEA) project, the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Finally, Core resources are being used to implement technology to facilitate the collection of new patient-based measures on adherence, lipodystrophy, depression, HRQL, and substance abuse.