EFFECTS OF AEROBIC EXERCISE ON COGNITION, MOOD AND FATIGUE FOLLOWING TBI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 3/24/2008 众所周知，认知功能减退、抑郁33和疲劳35 -37在TBI患者中比在一般人群中更为普遍，这些疾病的治疗是TBI患者康复和改善生活质量的关键挑战。虽然有氧运动已被证明可以改善普通人群的认知和情绪，但对TBI患者的研究有限。然而，运动已被证明可以有效改善患有其他疾病的患者的认知，抑郁和疲劳，例如癌症，多发性硬化症（MS），纤维肌痛，痴呆症，慢性疲劳综合征，57慢性阻塞性肺疾病，58和老年人。44，59，60 虽然有氧运动治疗计划可能对TBI患者同样有效，但研究尚未支持这一前提。拟议的研究将a）检查有氧运动干预对改善TBI后认知、抑郁和疲劳的有效性，B）评估TBI后运动对生活满意度的影响，以及c）探索TBI个体中介导有氧运动有效性的个人和损伤特征。 干预的效果将通过一项随机临床试验进行检查，该试验采用交叉设计，评估16周有氧运动计划的客观和主观效果。更具体地说，每个人都将接受个人访谈，自我报告和神经心理学测试，旨在测量认知，情绪，疲劳和生活满意度。预计约112名符合所有合格性标准的个体将完成整个研究。认知、情绪、疲劳和生活满意度的评估将在干预开始前、干预后立即和干预后三个月进行。 该研究还将研究神经营养生长因子（BDNF和VEGF）在改善情绪功能，认知能力和疲劳方面的作用。 假设：认知功能，情绪和疲劳症状将在8周的运动干预后改善。这种改善将与BDNF和VEGF水平的增加相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 3/24/2008 It is well accepted that reduced cognitive functioning,33 depression34 and fatigue35-37 are much more prevalent in individuals with TBI than in the general population, and the treatment of these disorders represents a key challenge to the rehabilitation and improved quality of life of persons with TBI. Although aerobic exercise has been shown to improve cognition and mood in the general population,38-45 research in individuals with TBI is limited.46-50 However, exercise has been shown to be effective in improving cognition, depression and fatigue in individuals with other medical conditions, such as cancer,51 multiple sclerosis (MS),52 fibromyalgia,53 dementia,54-56 chronic fatigue syndrome,57 chronic obstructive pulmonary disease,58 and in the elderly.44,59,60 While an aerobic exercise treatment program may be similarly effective for individuals with TBI, research does not yet support this premise. The proposed study will a) examine the efficacy of an aerobic exercise intervention for improving cognition, depression and fatigue after TBI, b) evaluate the effect of post-TBI exercise on life satisfaction, and c) explore personal and injury characteristics that mediate effectiveness of aerobic exercise in individuals with TBI. The effects of the intervention will be examined using a randomized clinical trial with a crossover design evaluating objective and subjective effects of a 16-week aerobic exercise program. More specifically, each person will undergo individual interviews, self reports and neuropsychological testing aimed at measuring cognition, mood, fatigue, and life satisfaction. Approximately 112 individuals who meet all eligibility criteria are expected to complete the entire study. Assessment of cognition, mood, fatigue, and life satisfaction will occur prior to beginning the intervention, immediately after the intervention and three months post-intervention. The study will also examine the role of neurotropic growth factors (BDNF and VEGF) in improving emotional function, cognitive performance, and fatigue. Hypothesis: Cognitive functioning, mood, and fatigue symptoms will improve following eight weeks of exercise intervention. This improvement will correlate with increased BDNF and VEGF levels.