PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设： 第一章 SPD患者将在对中央执行功能敏感的几种不同测试中表现出言语和视觉空间刺激的损害（即，维持加操纵，双任务处理：时间共享，和上下文处理），这是不成比例的，他们的维护只有性能，类似于以前的结果，精神分裂症。 （二） 这些缺陷不会被视觉注意/知觉整合缺陷或临床症状所解释。 第三章 基于性能的功能能力的措施将受损的SPD和性能在这些任务将与中央执行功能，包括上下文处理，双任务的时间共享，以及维护和操纵工作记忆。 四、 胍法辛仅在维持加操作任务、上下文处理、双任务时间分配以及功能能力测量上改善SPD患者的表现。 第五章） 胍法辛在仅维持工作记忆、简单记忆广度和情景记忆测量方面没有显著改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: 1) SPD patients will demonstrate impairment across verbal and visuospatial stimuli in several different tests sensitive to central executive functions (i.e., maintenance plus manipulation, dual-task processing: time sharing, and context processing) that is disproportionate to their maintenance-only performance, similar to previous results in schizophrenia. 2) These deficits will not be accounted for by visual attention/perceptual integration deficits or clinical symptoms. 3) Performance-based measures of functional capacity will be impaired in SPD and performance on these tasks will be related to central executive functioning, including context processing, dual-task time sharing, and maintenance and manipulation working memory. 4) Guanfacine will improve performance in SPD patients only on the maintenance plus manipulation task, context processing, dual-task time sharing, as well as on the functional capacity measures. 5) No significant improvement with guanfacine will be seen on maintenance only working memory, simple memory span, and measures of episodic memory.