NEW DIRECTIONS IN THE GENETICS OF IMPULSIVITY AND AGGRESSION

冲动和攻击性遗传学的新方向

• 批准号: 7718103
• 负责人: Larry J Siever
• 金额: $ 6.05万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718103
• 关键词: Accounting; Aggressive behavior; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Fenfluramine; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Grant; Impulsivity; Individual; Institution; Light; Measures; Morbidity - disease rate; Patients; Personality Disorders; Prolactin; Purpose; Research; Research Personnel; Resources; Serotonin; Source; United States National Institutes of Health; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposed study is to investigate the genetic contribution to impulsive aggressive behavior in patients with personality disorders, utilizing known polymorphisms in serotonin-related genes. Impulsive aggressive behavior is prevalent in patients with personality disorders and accounts for a substantial portion of the morbidity associated with these disorders. It is logical to investigate the association between genotype in serotonin-related genes and impulsive aggression in patients with personality disorders, in light of the observations that: 1) decreased serotongergic activity in the central nervous systgem has been demonstrated in personality disordered patients with impulsive aggressive behavior; 2) impulsive aggression has been shown to be at least partially heritable; 3) serotonin-related polymorphisms (variability in genotype) have been described, allowing for the characterization of genotype in individual subjects. In addition, we propose to measure central serotonin function utilizing the prolactin response to fenfluramine to allow for comparisons with both genotype and clinical phenomena.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究的目的是研究人格障碍患者脉冲侵袭行为的遗传贡献，利用5-羟色胺相关基因中的已知多态性。 在具有人格障碍的患者中，冲动性侵略行为普遍存在，并且占与这些疾病相关的发病率的很大一部分。 逻辑研究人格障碍患者的5-羟色胺相关基因中的基因型与脉冲攻击之间的关联是合乎逻辑的，鉴于以下观察结果：1）中枢神经系统中血清毒素活性的降低已在人格障碍患者的脉冲攻击行为的患者中被证明； 2）冲动侵略至少是部分遗传的； 3）已经描述了与5-羟色胺相关的多态性（基因型的变异性），从而允许在单个受试者中表征基因型。 此外，我们建议利用催乳素对芬氟拉明的反应来测量中央血清素功能，以便与基因型和临床现象进行比较。