STRUCTURAL NEUROIMAGING OF EARLY ONSET/ADOLESCENT BPD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 9/18/2007 交界性人格障碍(BPD)是一种以情绪调节不良和冲动控制不良为特征的致残性障碍。众所周知，这种疾病仍然很难有效治疗，许多患者对最广泛接受的治疗策略反应很差或部分有效。出于这些原因，开发早期识别和预防BPD的方法是精神卫生界的当务之急。这项研究将侧重于早发性BPD，并研究符合BPD标准的年龄较大的儿童和青少年，以努力开始使用磁共振成像来表征早期人群中这种疾病的潜在神经生物学特征。 AIMS：(协议，第3页) 1.研究符合BPD诊断标准的15-18岁青少年的脑总体积、总脑体积、脑室体积、皮质灰质、前额叶皮质特定区域包括前扣带回、眶前叶皮质和背外侧前额叶皮质以及杏仁核的结构差异。 2.调查患有BPD的青少年是否表现出与成人BPD类似的异常表现，包括特定的ACC灰质体积减少(BA 24)。 假设：(协议，第3页) 1.患有BPD的青少年将表现出ACC的减少，但总的脑体积、脑室和大脑体积与正常对照青少年相似。 2.青春期BPD患者杏仁核体积与正常对照组无明显差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 9/18/2007 Borderline Personality Disorder (BPD) is a disabling disorder characterized by poor emotion regulation and poor impulse control. The disorder remains notoriously difficult to treat effectively, with many patients responding poorly or partially even to the most widely accepted treatment strategies. For these reasons, developing methods of early identification and prevention of BPD is an urgent priority for the mental health community. This study will focus on early-onset BPD and study older children and adolescents who meet criteria for BPD, in efforts to begin to characterize the underlying neurobiology of the disorder in earlier age populations using magnetic resonance imaging. Aims: (Protocol, Page 3) 1. To examine structural differences in total brain volume, total cerebrum volume, ventricular volume, cortical gray matter, particular areas of the prefrontal cortex including anterior cingulate gyrus, orbital frontal cortex and dorsal lateral prefrontal cortex, and amygdala in adolescents aged 15-18, meeting criteria for BPD compared to normal control adolescents. 2. To investigate whether adolescents with BPD demonstrate similar abnormal findings seen in adult BPD including specific reductions in gray matter volume in ACC (BA 24). Hypotheses: (Protocol, Page 3) 1. Adolescents with BPD will exhibit reductions in ACC but have total brain volumes, ventricular and cerebrum volumes similar to normal control adolescents. 2. Amygdalar volumes in adolescent BPD will not differ from normal control adolescents.