THE IMPACT OF AN ANTISTATIC CHAMBER ON RESPONSE TO HFA ALBUTEROL DURING NOCTURNA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 沙丁胺醇用于治疗急性哮喘症状，通常通过定量吸入器MDI通过带阀的保持室VHC递送。VHC内壁上的静电荷减少了药物递送，并且减少电荷增加了到达气道的药物量。然而，没有关于减少急性支气管痉挛患者静电荷的临床相关性的数据，其中效果可能是最重要的。在这项研究中，我们假设通过抗静电VHC输送HFA沙丁胺醇将改善夜间哮喘期间的支气管扩张反应。当10名夜间哮喘受试者从哮喘中自发醒来或在CRC中于凌晨4点醒来时，将以20分钟间隔接受1、1和2喷HFA沙丁胺醇治疗。药物将以随机双盲交叉方式通过静电和抗静电VHC递送。将在每次给药前后测量FEV 1。将使用脉搏血氧仪连续测量心率和O2饱和度。终点将是可达到的最大FEV 1和达到80%患者个人最佳状态的时间。将测量心率，以确定减少静电荷是否会增加全身效应。本研究的结果将表明减少静电荷是否能改善急性支气管痉挛期间对HFA沙丁胺醇的反应，并可能影响处方的腔室类型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Albuterol is used to treat acute asthma symptoms and often is delivered by metered dose inhaler MDI through a valved holding chamber VHC. Electrostatic charges on the inner walls of VHCs decreases drug delivery and reducing the charge increases the amount of drug reaching the airways. However, there are no data on the clinical relevance of reducing the static charge in patients with acute bronchospasm where the effect might be most important. In this study, we are hypothesizing that the delivery of HFA albuterol through an antistatic VHC will improve bronchodilator response during nocturnal asthma. Ten subjects with nocturnal asthma will be treated with 1, 1, and 2 puffs of HFA albuterol at 20 minute intervals, when they wake up spontaneously from asthma or are awoken at 4 a.m in the CRC. The drug will be delivered by static and antistatic VHC in a randomized double-blind cross over manner. FEV1 will be measured before and after each dose. A pulse oximeter will be used to measure heart rate and O2 saturation continuously. The end points will be the maximum achievable FEV1 and the time to reach 80% of the patients personal best. Heart rate will be measured in order to determine whether decreasing the static charge increases systemic effects. The results of this study will indicate whether reducing the static charge improves response to HFA albuterol during acute bronchospasm and may affect which type of chamber is prescribed.