Phase 1 and Phase 2 Clinical Trials of Cancer Chemoprevention Agents

此次采购的目的是对国家癌症研究所（NCI）癌症预防部（DCP）赞助的癌症预防剂进行多个早期阶段（1期和2期）临床试验，并建立由一个或多个合作机构组成的基础设施来进行这些试验。这些试验将通过评估这些药物对其分子靶点的生物学效应和确定临床相关因素来评估各种药物的癌症预防潜力。

The purpose of this procurement is to conduct multiple early phase (Phase 1 and Phase 2) clinical trials of the National Cancer Institute (NCI), Division of Cancer Prevention (DCP)-sponsored cancer preventive agents and to establish the infrastructures composed of one or more collaborating institutions that will perform these trials. The trials will assess the cancer preventive potential of various agents by evaluating the biologic effects of these agents on their molecular targets and by determining clinically relevant correlates.