NEUROIMAGING CORE

神经成像核心的总体目标是首先实现结构性、 470名受试者的三个招募中心的灌注和弥散张量磁共振成像，有两个或更多的磁共振成像 关于260个受试者。第二，对结构磁共振图像进行包括强度在内的自动图像处理 结构MRI的归一化、分割、空间归一化和脑自动分析 结构使用自由冲浪软件。核心将：为影像集合提供整体凝聚力 数据，创建用于在程序范围内访问共享信息的数据存储库，支持程序范围内 制定方法，并将确保统一的获取方法，以便在 不同的站点可以汇集在一起。 1)建立结构MRI(T1和FLAIR)、扩散张量MRI和动脉的协调采集 所有三个采集点(加州大学旧金山分校、加州大学戴维斯分校和U So Cal)的自旋标记磁共振灌注成像； 2)在VA/UCSF神经退行性疾病成像中心进行所有MRI扫描 3)建立质量保证程序，确保3个采集点MRI采集的持续质量控制； 4)对所有3个站点采集的MRI数据进行存档和管理； 5)协调放射科医生的MRI读数，维护临床质量控制和评分员的可靠性 读数，以及在MRI上识别腔隙梗塞和皮质卒中的一致性； 6)进行强度校正(偏置场校正)； 7)基于期望的结构MRI(GM、WM、CSF、WML)图像分割 最大限度地利用软件。 8)开发改进的MRI分割技术，提供更敏感的变化测量 脑结构(例如，T-1加权扫描的WM强度损失) 9)所有数据的空间规格化。 10)执行自由冲浪分析，包括量化皮质厚度测量和 包括海马体总体积在内的脑区包裹性 11)确保评分员的可靠性，并继续对上述所有手动步骤进行评分员测试- 12)维护原始和处理数据的图像库和所有结果的数据库。 13)及时向PPG成员提供原始和处理后的图像数据； 14)向要求提供数据的外部合格调查人员提供原始和经过处理的图像和数据； 与数据共享计划保持一致。

The overall goal of the Neuroimaging core is first to achieve homogeneous acquisition of structural, perfusion, and diffusion tensor MRI at the three recruitment centers on 470 subjects, with two or more MRIs on 260 subjects. Second, to perform automated image processing of structural MRI including intensity normalization, segmentation of structural MRI, spatial normalization, and automated analysis of brain structure using Freesurfer software. The Core will: provide an overall cohesion to the collection of imaging data, create a data repository for program wide access to shared information, support program wide methodological development, and will ensure uniform methods of acquisition, so that data collected at the different sites can be pooled. 1) Establishing harmonized acquisition of structural MRI (T1 and FLAIR), diffusion tensor MRI, and arterial spin label perfusion MRI at all three acquisition sites (UC San Francisco, UC Davis, and U So Cal); 2) Performing all MRI scans at the Center for Imaging of Neurodegenerative Diseases, VA/UCSF 3) Establishing QA procedures and insuring continued quality control of MRI acquisition at all 3 sites; 4) Archiving and managing all MRI data acquired at all 3 sites; 5) Coordinating MRI readings by radiologists and maintaining quality control and rater reliability of clinical readings, and consistency in identifying lacunar infarctions and cortical strokes on MRI; 6) Performing intensity corrections (bias field corrections); 7) Image segmentation of structural MRI (GM, WM, CSF, white matter lesions (WMLs), using Expectation maximization likelihoold software. 8) Develop improved MRI segmentation techniques which provide more sensitive measures of changes in brain structure (e.g. loss of intensity of WM on T-1 weighted scans) 9) Spatial normalization of all data . 10) Performing Freesurfer analysis including quantification of cortical thickness measurements and parcelation of brain regions including total hipppcampal volume 11) Ensuring rater reliability and continue rater testing for all manual steps in the above- 12) Maintaining an image repository of raw and processed data and data base of all results. 13) Providing raw and processed image data to members of the PPG on a timely basis; 14) Providing raw and processed images and data to outside qualified investigators who request data, consistent with the data sharing plan.