The Mobile Toolbox for Monitoring Cognitive Function - Project

用于监测认知功能的移动工具箱 - 项目

• 批准号: 10454847
• 负责人: MICHAEL W WEINER
• 金额: $ 69.17万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10454847
• 关键词: Adult; Age; Alzheimer' s Disease; Android; Assessment tool; Brain Health Registry; Calibration; Cellular Phone; Clinical; Cognition; Cognitive; Computer software; Computers; Consent; Custom; Data; Data Analyses; Data Collection; Diagnostic; Disease; Emotions; Ethnic Origin; General Population; Geography; Goals; Gold; Health; Health Status; Impaired cognition; Intelligence; Internet; Libraries; Longevity; Measures; Methodology; Methods; Monitor; Moods; Neuropsychological Tests; Parkinson Disease; Participant; Patient Self-Report; Personality; Procedures; Property; Protocols documentation; Psychometrics; Public Domains; Questionnaires; Race; Registries; Research; Research Personnel; Research Project Grants; Resources; Respondent; Risk; Sampling; Self Administration; Series; Testing; United States National Institutes of Health; Validation; Withdrawal; base; biological sex; cognitive ability; cognitive change; cognitive function; cognitive task; cognitive testing; data management; demographics; design; flexibility; follow up assessment; follow-up; healthy aging; innovation; instrument; mobile application; programs; public repository; response; theories; validation studies

Project Summary Our research project will be a collaborative effort supported by all of the MobileToolbox Cores. The project will function as the vehicle within which we develop and psychometrically evaluate our cognitive assessment tools. We will do this by accomplishing the following specific aims. Aim 1: We will develop a repository of public-domain cognitive ability measures that enhance the assessment of cognitive change across the lifespan by enabling self-administered testing via iOS and Android smartphones. The MobileToolbox measures will be designed around the technical specifications of a flexible and open software platform that enables external researchers to customize use of the mobile app to fit the needs of their studies. Researchers will be able to choose from a diverse selection of cognitive measures, including several cognitive tasks highly sensitive to change, along with measures of contextual variables of relevance to cognitive functioning (e.g., mood, personality, health status). Aim 2: Evaluate the psychometric properties of MobileToolbox instruments through implemention of a series of data collection protocols aimed at calibration, norming, and face-to-face validation against existing gold standards. We will calibrate Item Response Theory based measures by administering them to a large (N=4,800) general population calibration sample. All newly developed MobileToolbox measures will be validated against existing gold standards in a sample of healthy adults ages 20-85. The validation protocol will include face-to-face administration of the NIH Toolbox Cognition Battery, core sub-tests of the Wechsler Adult Intelligence Scale (WAIS-IV), and additional tests as needed. During this cross-sectional validation session, respondents (N=260) will complete the self-administered MobileToolbox via smartphone in an un-proctored setting. Additional validation will be undertaken in existing clinical (e.g., cognitively impaired, Parkinson’s disease) and general population (e.g. Healthy Aging Study, N=100,000) samples. Finally, we will identify normative values for the MobileToolbox measures using a large, nationally-representative sample (N=6,800). Sub-samples of respondents will be used to identify normative cognitive change by completing 3-, 12- and 24- month follow-up assessments.

项目摘要 我们的研究项目将是一个合作的努力，由所有的移动通信核心的支持。该项目将 作为我们开发和心理测量评估我们的认知评估工具的工具。 我们将通过实现以下具体目标来实现这一目标。 目标1：我们将开发一个公共领域认知能力指标库， 通过iOS进行自我管理测试，评估整个生命周期内的认知变化， Android智能手机。移动通信措施将围绕一个 灵活开放的软件平台，使外部研究人员能够自定义移动的应用程序的使用，以适应 他们学习的需要。研究人员将能够从多种认知测量方法中进行选择， 包括几个对变化高度敏感的认知任务，沿着情境变量的测量， 与认知功能的相关性（例如，情绪、个性、健康状况）。 目的2：通过实施一个 一系列数据收集协议，旨在校准、规范化和面对面验证， 现有的黄金标准。我们将校准项目反应理论为基础的措施，通过管理他们， 一个大的（N= 4，800）一般人群校准样本。所有新开发的移动通信措施都将 在20-85岁的健康成年人样本中验证了现有的黄金标准。确认方案将 包括面对面管理NIH认知测验，韦氏成人核心子测验， 智力量表（WAIS-IV），并根据需要进行其他测试。在这次横向验证会议期间， 受访者（N=260）将通过智能手机在无监督的 设置.将在现有临床（例如，认知障碍，帕金森氏症 疾病）和一般人群（例如健康老龄化研究，N= 100，000）样品。最后，我们将确定 使用一个大的，具有全国代表性的样本（N= 6，800）的Mobiletrance措施的规范值。 受访者的子样本将被用来确定规范认知变化，通过完成3-，12-和24- 一个月的后续评估。