SACCADIC EYE MOVEMENT STUDIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们工作的最终目标是了解大脑的功能。为了做到这一点，我们研究输出（运动）部分，使用眼动系统作为模型，特别是那些被称为扫视眼球运动的快速运动。 我们继续我们的眼跳产生的机制的研究，最近集中在脑桥被盖网状核（nucleus reticularis tegmenti pontis，nerve）的功能。我对脑桥喙部长导联爆发神经元的研究（1）发现了可能触发扫视的神经元，并推翻了这些神经元的其他几个假设功能。 我们对nerve失活的研究（2）表明，nerve是产生扫视所必需的，因为它的失活会导致同侧扫视的麻痹。 最后，我们的初步发现（3）表明，由上级丘发出并由小脑中继到小脑的指令信号是正常扫视所必需的。 我们还将继续研究其他眼内结构。 我们最近总结了（4）我们以前在锋面平滑追踪区的工作。 我们之前对眼力学的研究导致了一种新的眼动力学理论治疗（5），详细说明了任何关于眼球运动如何由大脑控制的假设的重要新约束。这些结果不仅促进了我们对大脑如何处理信息以根据该信息制定行动的理解，而且它们也是基于目前临床上常用的眼动体征的鉴别神经学诊断以及我们对眼动过程的理解的基础。它们还为中枢神经系统功能的更复杂方面的研究提供了基础，例如运动系统之间的相互作用（例如，定向期间的眼睛和头部）或感觉和运动系统（例如，视觉和眼动系统）和更抽象的功能，如注意力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate goal of our work is to understand how the brain functions. To do this, we study the output (motor) portions, using the oculomotor system as a model, specifically those fast movements known as saccadic eye movements. We continue our studies of mechanisms of saccade generation and have recently focused on the function of the nucleus reticularis tegmenti pontis (nrtp). My investigation of the long-lead burst neurons of the rostral pons (1) identified neurons that may act as a trigger for saccades and disproved several other previously hypothesized functions for these neurons. Our study of nrtp inactivation (2) showed that the nrtp is necessary for the production of saccades since its inactivation leads to paralysis of ipsilateral saccades. Finally, our preliminary findings (3) show that the command signal issued by the superior colliculus and relayed by the nrtp to the cerebellum is necessary for normometric saccades. We also continue to investigate other oculomotor structures. We have recently summarized (4) our previous work on the frontal smooth pursuit area. Our previous study on eye mechanics led to a new theoretical treatment (5) of the dynamics of eye detailing important new constraints on any hypothesis of how eye movements are controlled by the brain. These results not only advance our understanding of how the brain processes information in order to formulate actions based on that information, but they are also basic to the differential neurological diagnosis based on eye-movement signs now commonly used clinically as well as to our understanding of oculomotor processes. They also provide a foundation for studies of more complex aspects of central nervous system function such as interactions between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) and more abstract functions such as attention.