MATERNAL-FETAL TRANSPORT OF NEUROTOXINS USING PET IMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：利用正电子发射计算机断层扫描(PET)成像技术，评估神经毒素在体内的母胎转运。 在一项涉及WNPRC繁殖群体中一只怀孕恒河猴的初步研究中，我们使用PET-CT成像来研究母婴之间的物质运输。这项研究的目的是评估体内多巴胺受体示踪剂从母亲到胎儿的转运。我们观察到示踪剂在富含多巴胺受体的胎儿纹状体中的快速转运和特异性摄取和滞留。这项研究论证了这种非侵入性技术的可行性。我们计划未来的工作，等待向NIH提交的拨款提案的资金支持。我们的目标是评估胎儿对环境神经毒素的摄取，以便对宫内神经毒素暴露的风险进行科学评估。这项研究使用了动物服务机构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To assess in vivo maternal-fetal transport of putative neurotoxins using PET imaging. We used PET-CT imaging to study maternal-fetal transport of materials in one preliminary study involving a pregnant rhesus macaque of the WNPRC breeding colony. The goal of this study was to assess the in vivo transport from the mother to the fetus of a dopamine receptor tracer. We observed rapid transport and specific uptake and retention of the tracer in the fetal striatum, which is rich with dopamine receptors. This study demonstrates the feasibility of this non-invasive technique. We plan future work pending the funding of a grant proposal submitted to the NIH. We aim to assess fetal uptake of environmental neurotoxins in order to make science-based risk assessment of neurotoxin exposure in utero. This research used Animal Services.