IMMUNOGENICITY OF HIV CANDIDATE VACCINES IN BABOONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类免疫缺陷病毒(HIV)在21年前被确定为艾滋病的病原体，该病毒已导致约2300万人死亡，估计已感染全球近4600万人。目前还没有有效的疫苗来防止病毒的进一步传播。在这项建议中，我们将在狒狒模型中检查新的候选艾滋病疫苗的免疫原性，以期找到适合人体试验的疫苗配方。这项拟议的项目总共需要60只狒狒。每组8到12只狒狒将被用来测试不同候选疫苗的免疫原性。我们计划每隔6到8个月用8到12只狒狒来测试每种候选疫苗的免疫原性。因此，测试的候选疫苗总数将从5到7个不等。整个提案的实验目标是评估不同候选疫苗的相对免疫原性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus (HIV) was identified as the causative agent of AIDS more then 21 years ago and the virus has killed approximately 23 million people and is estimated to have infected nearly 46 million people worldwide. No effective vaccine is available for prevention of further spread of the virus. In this proposal, we will examine the immunogenicity of novel candidate AIDS vaccines in the baboon model to hopefully identify a suitable vaccine formulation for human trials. A total of 60 baboons are requested for the proposed project. Groups of 8 to 12 baboons will be used for testing the immunogenicity of different candidate vaccines. We plan to use 8 to 12 baboons for testing the immunogenicity of each candidate vaccine at 6 to 8 month intervals. Therefore, the total number of vaccine candidates tested will range from 5-7. The experimental objective for the entire proposal is to evaluate the relative immunogenicity of different vaccine candidates.