ROLE OF TELOMERES WITH INSULIN RESISTANCE AND CORONARY DISEASE IN HEALTH CARE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的具体目标包括在超重或肥胖的非西班牙裔白人、非西班牙裔黑人和拉丁裔成年人的社区样本中检查白细胞端粒限制片段长度与氧化应激和胰岛素抵抗的关系。其次，在超重或肥胖的非西班牙裔白人、非西班牙裔黑人和拉丁裔成年人的社区样本中，检查白细胞端粒限制片段长度与冠状动脉钙化以及新的和传统的心血管危险因素的相关性。最终的具体目标将是在非西班牙裔白人、非西班牙裔黑人和拉丁裔成年人的社区样本中检查白细胞端粒限制片段长度与常规多变量冠心病风险评分(Framingham Risk Score)的相关性。端粒限制片段长度可能是冠心病和胰岛素抵抗风险的有用标志，而胰岛素抵抗是糖尿病和冠心病的先兆。非西班牙裔白人和少数民族之间的健康差异已经被很好地记录下来，其中包括胰岛素抵抗和冠心病。因此，端粒长度作为种族和民族疾病风险的解释变量可能有额外的作用。从这项研究中获得的知识将有助于预防冠心病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims of this study include the primary one of examing the association of leukocyte telomere restriction fragment length with oxidative stress, and insulin resistance in a community sample of overweight or obese Non-Hispanic White, Non-Hispanic Black, and Latino adults. Secondarily, to examine the association of leukocyte telomere restriction fragment length with coronary artery calcification as well as novel and traditional cardiovascular risk factors in a community sample of overweight or obese Non-Hispanic White, Non-Hispanic Black, and Latino adults. The final specific aime will be to examine the association of leukocyte telomere restriction fragment length with a conventional multivariable coronary heart disease risk score (Framingham Risk Score) in a community sample of Non-Hispanic White, Non-Hispanic Black, and Latino adults. Telomere restriction fragment length could be a useful marker for risk of CHD and insulin resistance, a precursor to both diabetes and CHD. Health disparities between Non-Hispanic Whites and minorities have been well documented and have included insulin resistance and coronary heart disease. Consequently, telomere length may have additional utility as an explanatory variable for disease risk across racial and ethnic groups. The knowledge gained from this study will help to prevent CHD.