EFFECT OF INCREASING T ON INSULN SENSITIVITY IN MEN WITH METABOLIC SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有几条证据一致地指出，男性的睾丸素和胰岛素之间存在反向关系，但目前关于因果关系的数据相互矛盾。一方面，服用睾丸素已被证明可以改善肥胖男性的胰岛素抵抗。另一方面，减肥已被证明可以提高睾丸激素水平。因此，需要建立这些关系的准确定义，并确定它们的因果决定因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several lines of evidence consistently point to an inverse relationship between testosterone and insulin in men, but current data on causality are conflicting. On the one hand, testosterone administration has been shown to ameliorate insulin resistance in obese men. On the other hand, weight loss has been demonstrated to increase testosterone levels. Thus, precise definitions of these relationships need to be established and their causative determinants defined.