CLINICAL STATUS AND BRAIN FUNCTIONING IN ADOLESCENTS AND ADULTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是评估处于精神分裂症进展不同阶段的受试者。 受试者可能是“前驱”（高临床风险）、首次发作、慢性或健康对照，这为研究者提供了关于表型标记物和进展预测因子的广泛视角和数据库。该研究旨在将精神分裂症疾病进展的临床，认知，神经影像学，电生理，激素和遗传标记与了解潜在的神经回路如何受到干扰联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to evaluate subjects who are at various stages of progression to schizophrenia. Subjects may be "prodromal" (high clinical risk), first episode, chronic, or healthy controls, which gives the investigators a broad perspective and database on phenotypic markers and predictors of progression. The study aims to link clinical, cognitive, neuroimaging, electrophysiological, hormonal and genetic markers of schizophrenia disease progression to the understanding of how the underlying neural circuits may be disturbed.