THE TRIALNET NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 TrialNet联盟的主要目的是在有发展T1 D风险或新诊断T1 D的个体中开发保护胰腺细胞功能的治疗的临床试验。 这些试验的最佳设计和完成取决于对T1 D自然史的了解和招募受试者的有效策略。 TrialNet 1型糖尿病自然史研究的目的是获得有关T1 D自然史和发病机制的信息，并促进招募和评估可能有资格参加T1 D预防试验的个人。 T1 D发展的TrialNet自然史研究分为三个阶段：第1阶段筛选，第2阶段基线风险评估和第3阶段随访风险评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of the TrialNet consortium is to develop clinical trials of treatments that protect pancreatic ¿-cell function, in individuals who are at risk for developing T1D or who have newly diagnosed T1D. Optimal design and completion of these trials depends upon knowledge of the natural history of T1D and effective strategies to recruit subjects. The goals of the TrialNet Natural History Study of the Development of Type 1 Diabetes are to gain information about the natural history and pathogenesis of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. The TrialNet Natural History Study of the Development of T1D is divided into three phases: Phase 1 Screening, Phase 2 Baseline Risk Assessment, and Phase 3 Follow-Up Risk Assessment.