RECOMBINANT HUMAN PROLACTIN FOR LACTATION INDUCTION/ PROLACTIN DEFICIENT MOTHERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 母乳喂养对母亲和婴儿有许多重要的健康影响。母乳喂养被认为可以降低婴儿感染、免疫系统疾病、特应性疾病和慢性病的风险。母乳喂养对母亲的心理和健康也有好处。因此，普遍建议母亲母乳喂养婴儿。在一些女性中，催乳素缺乏可能是母乳喂养的障碍。完全性催乳素缺乏症可能源于既往的脑下垂体手术和/或放射治疗、希恩综合征或由Pit-1突变引起的先天性催乳素缺乏症。催乳素替代疗法很可能在治疗这些患者的哺乳不足方面非常有效。这项开放标签的先导性研究将首次检验r-hPRL在完全催乳素缺乏的母亲中诱导哺乳的安全性和有效性，目前还没有治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breastfeeding has many important health implications for mothers and infants. Breastfeeding is thought to reduce an infant's risk of infections, immune system diseases, atopic diseases, and chronic diseases. There are also both psychological and health benefits for breastfeeding mothers. Thus, it is universally recommended that mothers breast feed infants. Prolactin deficiency can be an obstacle to breastfeeding in some women. Complete prolactin deficiency may result from previous pituitary surgery and/or radiation, Sheehan's syndrome, or congenital prolactin deficiency caused by Pit-1 mutations. Prolactin replacement is likely to be highly effective in treating these patients for lactation insufficiency. This open-label pilot study will be the first to examine the safety and efficacy of r-hPRL to induce lactation in mothers with complete prolactin deficiency, for whom there is currently no treatment.