CLINICAL TRIAL: LOOKAHEAD STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Look Advance(糖尿病健康行动)是一项多中心随机临床试验，旨在检验生活方式干预的效果，该干预旨在通过减少卡路里摄入量和锻炼来实现并长期保持减肥。展望未来，重点关注受超重和肥胖影响最大的疾病--2型糖尿病，以及导致最大发病率和死亡率的结果--心血管疾病。 展望未来的主要目标是研究这两种干预措施对主要心血管事件：心脏病发作、中风和心血管相关死亡的影响。展望未来还将调查干预措施对其他心血管疾病相关结局、心血管危险因素和全因死亡率的影响。其他结果包括：糖尿病控制和并发症、健身、一般健康、与健康相关的生活质量和心理结果。将评估生活方式干预相对于糖尿病支持和教育的成本和成本效益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Look AHEAD (Action For Health in Diabetes) is a multicenter randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. The primary aim of Look AHEAD is to study the effects of the two interventions on major cardiovascular events: heart attack, stroke and cardiovascular-related death. Look AHEAD also will investigate the impact of the interventions on other cardiovascular disease-related outcomes, cardiovascular risk factors, and all-cause mortality. Additional outcomes include: diabetes control and complications, fitness, general health, health-related quality of life and psychological outcomes. The cost and cost effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed.