PARTIAL AND COMPLETE GROWTH HORMONE BLOCKADE IN POLYCYSTIC OVARY SYNDROME

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）的综合征知之甚少，影响5-8%的育龄妇女，并导致不孕症以及糖尿病和心脏病的风险增加。该提案的长期目标是提高对PCOS病理生理学的理解，以便开发更有效的治疗方法。 该提案使用一种新的生长激素拮抗剂作为生理探针，以分离生长激素在这种复杂且知之甚少的疾病中的作用。该建议的短期目标是确定生长激素和IGF-1对PCOS过度胰岛素抵抗和高雄激素血症的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The poorly understood syndrome of Polycystic Ovary Syndrome (PCOS) affects 5-8% of reproductive age women and results in infertility as well as an increased risk of diabetes and heart disease. The long term objective of this proposal is to improve understanding of the pathophysiology of PCOS in order that more effective treatments can be developed. This proposal uses a new growth hormone antagonist as a physiological probe to isolate the effects of growth hormone in this complex and poorly understood disease. The short term goal of this proposal is to determine the contribution of growth hormone and IGF-1 to the excess insulin resistance and hyperandrogenism in PCOS.