VALIDATION OF SELF-REPORT TOOL TO SCREEN FOR PERIODONTAL DISEASE AMONG PREGNANT

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：1.验证自我报告工具在孕妇牙周病筛查中的应用 2.比较有无牙周病妇女对口腔病原体的炎症反应。 参与者：在北卡罗来纳州大学妇女诊所接受护理的孕妇 程序（方法）：合格的妇女将在产前护理访问期间招募。同意参加的妇女将完成一份旨在筛查牙周病存在的问卷。 在完成问卷调查的14天内，入选的女性将接受标准化的牙周健康检查，以确定临床牙周病的存在和程度。在牙周健康检查时，将收集并储存龈沟液和牙菌斑样本以供将来分析。妇女还将被要求提供静脉血样本，以检查对口腔病原体的炎症反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purposes: 1. To validate the use of a self report tool to screen for periodontal disease among pregnant women 2. To compare inflammatory responses to oral pathogens between women with and without periodontal disease. Participants: Pregnant women receiving care at the University of North Carolina Women s Clinic Procedures (methods): Eligible women will be recruited during prenatal care visits. Women who agree to participate will complete a questionnaire designed to screen for presence of periodontal disease. Within 14 days of completion of the questionnaire, enrolled women will undergo a standardized periodontal health exam to determine presence and extent of clinical periodontal disease. At the time of the periodontal health exam, gingival crevicular fluid and plaque specimens will be collected and stored for future analyses. Women will also be asked to provide a sample of venous blood to examine for inflammatory responses to oral pathogens.