Point of care detection of respiratory viruses

描述(申请人提供)：呼吸道感染是发病率和死亡率的主要原因，并对全球医疗成本和生产率产生重大影响。快速、简单和可靠的护理点(POC)检测方法是有效抗击这些感染的关键。理想情况下，这些测试对于环境存储来说应该是廉价且稳定的。作为POC方法，目前的病原体检测方法失败了，因为它们太慢、太贵，和/或需要昂贵的仪器、冷冻箱或训练有素的人员。因此，呼吸系统疾病的病原体往往无法确定。该项目的目标是开发和集成改进的化学和仪器，以提供快速(30分钟)、可靠的POC检测测试，每次测试不到10美元，而且足够简单和强大，足以让护士在诊所或在家中执行。公共卫生相关性：快速、简单、低成本、可靠的护理点检测方法对于有效抗击呼吸道感染至关重要。理想的医疗点测试可以在诊所、野外、战区甚至在家里进行有限的培训即可操作和解释，它将改善患者的预后，通过减少不适当的治疗和住院来降低成本，并将有助于限制感染的传播。

DESCRIPTION (provided by applicant): Respiratory infections are a leading cause of morbidity and mortality and have a dramatic impact on global healthcare costs and productivity. Rapid, simple, and robust point of care (POC) detection methods is crucial to effectively combat these infections. Ideally, these tests should be inexpensive and stable for ambient storage. Current methods of pathogen detection fail as a POC method because they are too slow, too expensive, and/or require expensive instrumentation, storage in freezers or highly trained personnel. Consequently, the etiological agents for respiratory diseases often go unidentified. The goal of this project is to develop and integrate improved chemistries and instrumentation to provide a rapid (30 minutes), reliable POC detection tests at less than $10 per test and that is simple and robust enough for a nurse to perform in the clinic or a patient at home. PUBLIC HEALTH RELEVANCE: Rapid, simple, low cost, robust point of care detection methods is crucial to effectively combat respiratory infections. Ideal points of care tests can be operated and interpreted with limited training in clinics, in the field, in warzones or even at home and will improve patient outcome, reduce costs by reducing inappropriate treatment and hospitalization and will help limit spread of infections.