STANDARD VALUES OF EOSINOPHIL-RELATED PARAMETERS FOR DATA COMPARISON

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 嗜酸性粒细胞是在白细胞介素3、5(IL-3、IL-5)和粒细胞巨噬细胞集落刺激因子(GM-CSF)刺激下在骨髓中发育的免疫细胞。成熟的嗜酸性粒细胞迁移到肠道，并参与寄生虫免疫，特别是对蠕虫的免疫。 嗜酸性粒细胞还与许多过敏性疾病有关，包括哮喘、特应性皮炎、药物反应和慢性荨麻疹。嗜酸性粒细胞相关的胃肠道疾病包括嗜酸性食管炎、嗜酸性胃肠炎和胶原性结肠炎。高嗜酸性粒细胞综合征包括嗜酸性粒细胞显著增加的患者。嗜酸性粒细胞还参与了由掺假食品引起的疾病，如嗜酸性粒细胞增多症、肌痛综合征和中毒油综合征。糖皮质激素已被用于治疗其中许多疾病；然而，长期使用类固醇会产生显著的副作用。 这种化验的值只能放在有意义的上下文中，并与正常患者的值进行比较。由于不同实验室在设备、技术和试剂方面的差异，文献价值通常是不够的。每个实验室都有必要为化验建立正常值。此外，正常的患者样本应该经常与研究参与者样本一起运行，以确认设备保持校准和技术不变。 该项目的目标是验证设备一致地进行校准和工作，并获得一系列正常值，以便在当前和未来的一些研究中与患者样本进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Eosinophils are immune cells that develop in the bone marrow in response to interleukins-3, -5 (IL-3, IL-5) and granulocyte macrophage colony stimulating factor (GM-CSF). Mature eosinophils migrate to the gut and are involved in parasitic immunity, especially to helminthes. Eosinophils are also associated with many allergic diseases including asthma, atopic dermatitis, drug reactions and chronic urticaria. Eosinophil-associated gastrointestinal diseases include eosinophilic esophagitis, eosinophilic gastroenteritis and collagenous colitis. The hypereosinophilic syndrome includes patients with marked increases in eosinophils. The eosinophil is also involved in diseases caused by adulterated food products such as eosinophilia myalgia syndrome and toxic oil syndrome. Glucocorticoids have been used as a treatment for many of these diseases; however, long-term steroid usage causes significant side effects. Values for such assays can only be placed in meaningful context with comparison against normal patient values. Because of inter-laboratory variations in equipment, technique, and reagents, literature values will usually not suffice. It is necessary for each laboratory to establish normal values for the assays. Further, normal patient samples should be frequently run alongside study participant samples, in order to confirm that the equipment remains calibrated and technique unchanged. The objective of this project is to verify that equipment is consistently calibrated and working, as well as to obtain a range of normal values against which to compare patient samples for a number of present and future studies.