NON-INVASIVE IMAGING OF GI INFLAMMATION USING MICROBUBBLE CEU

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 炎症性肠病(IBD)是一种常见的慢性炎症性疾病，但目前还没有一种非侵入性的方法来评估疾病的位置、严重程度和程度。最近发表的动物数据表明，使用经腹部超声增强的气态微泡可能提供一种可靠的、非侵入性的手段来检测和量化肠道炎症区域。本研究将评估超声造影(CEU)作为IBD患者诊断工具的作用。我们假设，慢性肠炎的严重程度和程度，通过CEU得出的视频强度分数来量化，将与从克罗恩病内窥镜炎症指数(CDEIS)获得的内窥镜得出的肠炎症指标相关。共有40名患者将参加研究，其中30名IBD患者和10名因其他原因接受结肠镜检查的患者。在结肠镜检查之前，将对小肠和大肠进行CEU评估，以评估新血管生成和肠道血流。CEU得出的视频强度评分与CDEIS之间的相关性将使用皮尔逊相关系数进行评估。IBD和非IBD受试者之间的视频强度比较将使用Wilcoxon秩和检验进行，次要目的是建立对微泡评分系统的敏感性的初步估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory bowel disease (IBD) is a common chronic inflammatory disorder, but a noninvasive method of assessing disease location, severity, and extent is currently not available. Recently published animal data suggests that using transabdominal ultrasound enhanced with encapsulated gaseous microbubbles may provide a reliable, noninvasive means to detect and quantify areas of intestinal inflammation. This study will evaluate the role of Contrast-enhanced ultrasonography (CEU) for use as a diagnostic tool in patients with IBD. We hypothesize that the severity and extent of chronic intestinal inflammation, as quantified by CEU-derived video intensity scores, will correlate with endoscopically-derived measures of intestinal inflammation as obtained from the Crohn's Disease Endoscopic Inflammatory Index (CDEIS). A total of 40 patients will be enrolled in the study, 30 patients with IBD and 10 patients undergoing colonoscopy for other reasons. Prior to colonoscopy CEU assessment of small and large intestine will be performed to evaluate neoangiogenesis and intestinal blood flow. The correlation between the CEU-derived video intensity score and CDEIS will be assessed using Pearson's correlation coeffient. Comparing video intensity between IBD and non-IBD subjects will be performed using the Wilcoxon rank sum test, with a secondary aim of establishing preliminary estimates of the sensitivity of the microbubble scoring system.