BIOBEHAVIORAL EFFECTS OF MINDFULNESS-BASED STRESS REDUCTION IN HIV

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们建议确定基于正念的减少（MBSR）计划是否比压力和应对写作控制条件（SCW）更有效：（1）提高免疫抵抗力，延缓HIV疾病进展（即T淋巴细胞亚群增加和病毒载量减少），（2）改善心理状态和生活质量，以及（3）确定这些效果是否受到练习量的调节以及正念变化的介导。我们假设，与迄今为止的证据一致，即：（1）与对照条件相比，MBSR训练将引起免疫状态的更大改善，如T淋巴细胞的增加，（2）尽管迄今为止还没有证据表明MBSR对HIV的临床有效性，但我们假设正念训练与对照条件相比将产生更大的病毒载量减少，（3）正念训练比对照组更能改善心理状态和幸福感。最后，我们还假设（4），免疫和心理变化的幅度将受到练习量的调节，并通过正念的增加来调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to determine whether the Mindfulness-Based Reduction (MBSR) program is more effective than a stress and coping writing control condition (SCW) in: (1) improving immune resistance and delaying HIV disease progression (i.e. increases in T-lymphocyte subsets and reductions in viral load), (2) improving psychological status and quality of life, and (3) to determine whether these effects are moderated by the amount of practice and mediated by changes in mindfulness. We hypothesize, consistent with the evidence to date, that: (1) MBSR training will elicit greater improvements in immune status as indexed by increases in T-lymphocytes than the control condition, (2) although there is no evidence of the clinical effectiveness of MBSR with HIV to date, we hypothesize that mindfulness training will produce greater reductions in viral load compared to the control condition, and (3) that mindfulness training will produce greater improvements in psychological status and well-being than the control condition. Finally, we also hypothesize (4) that the magnitude of immune and psychological changes will be moderated by the amount of practice and mediated by increases in mindfulness.