ISOLATED MUSCLE TRAINING BEFORE AND AFTER LUNG TRANSPLANTATION IN HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 测试患者在肺移植恢复后无法恢复正常运动耐量的原因是否是由于骨骼肌的肌病变化，这些变化对运动限制有很大影响。骨骼肌肌病的改变可能源于与原始疾病状态(主要是COPD)有关的肌肉特定疾病、移植后使用的免疫抑制治疗的作用，或者原始疾病的长期性质导致的废用性萎缩。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test whether the inability of patients to regain normal exercise tolerance after recovery from lung transplantation is due to skeletal muscle myopathic changes that contribute significantly to exercise limitation. Skeletal muscle myopathic changes may originate from either a muscle specific disease connected to the original disease state (mainly COPD), action of the immunosuppressive therapies used after transplant, or a disuse atrophy resulting from the long term nature of the original disease.