YOGA STRESS REDUCTION SUB-STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 主要研究目的 1. 比较活性治疗组和对照组之间的情感和睡眠质量（使用问卷）的变化（基线至6个月）。 2. 比较活性药物治疗组和对照组之间交感神经系统活动（使用静息心率、静息血压和尿液中肾上腺素和去甲肾上腺素的静息水平测量值）和肾上腺皮质活动指数（使用唾液和尿液中皮质醇的测量值以及腰围/臀围比）的变化（基线至6个月）。 3. 比较活性治疗组和对照组之间慢性炎症（通过C反应蛋白的血液水平测量）和免疫功能（通过免疫球蛋白伊加的唾液水平测量）的变化（基线至6个月）。 次要研究目的 4. 比较活性药物治疗组和对照组睡前唾液褪黑激素水平的变化（基线至6个月）。 5. 研究情绪变化（基线至6个月）与循环皮质醇变化之间的相关性，以及唾液褪黑激素变化与睡眠质量变化之间的相关性。 6. 评估在试验期间通过瑜伽干预实现的压力标志物变化是否在接下来的6个月内持续（在维持阶段）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS Primary Study Aims 1. To compare change (baseline to 6 months) in affect and sleep quality (using questionnaires) between the active treatment and the control groups. 2. To compare change (baseline to 6 months) in sympathetic nervous system activity (using measurements of resting heart rate, resting blood pressure, and resting levels of adrenalin and noradrenalin in the urine) and an index of cortical adrenal activity (using measurements of cortisol in the saliva and urine and waist-to-hip circumference ratio) between the active treatment and the control groups. 3. To compare change (baseline to 6 months) in chronic inflammation (measured by blood levels of C-reactive protein) and immune function (measured by salivary levels of immunoglobulin IgA) between the active treatment and the control groups. Secondary Study Aims 4. To compare change (baseline to 6 months) in salivary melatonin level at bedtime between the active treatment and the control group. 5. To examine the correlations between change (baseline to 6 months) in affect and change in circulating cortisol and between change in salivary melatonin and change in sleep quality. 6. To assess whether the changes in stress markers achieved by the yoga intervention during the trial are sustained over the following 6 months (during the maintenance phase).