FUNCTIONAL CORRELATES OF GPI DEEP BRAIN STIMULATION IN PRIMARY DYSTONIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对于对药物治疗无反应的肌张力障碍患者，使用脑深部电刺激（GPi DBS）进行手术治疗可以减轻症状。然而，这种干预工作的确切机制尚不清楚。我们推测，肌张力障碍是由额叶大脑皮层和皮质下大脑区域之间的功能连接紊乱引起的，这些区域参与运动调节。在拟议的研究中，我们将测试这一功能障碍是否可以通过有效的GPi DBS纠正的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For dystonia patients who do not respond to medical therapy, surgical treatment with deep brain stimulation (GPi DBS) can reduce symptoms. However, the precise mechanism by which this intervention works is unknown. We hypothesize that dystonia is caused by a disturbance of the functional connections between the frontal cerebral cortex and subcortical brain regions involved in movement regulation. In the proposed studies, we will test the hypothesis whether this functional disturbance can be corrected by effective GPi DBS.