Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol

描述(由申请人提供) 理查德·佩尔蒂埃博士的长期职业目标是成为一名独立调查员，能够领导先进的气溶胶暴露评估研究，为了解暴露及其对健康的具体影响做出有目的的贡献。 在指导研究阶段(K99)，Peltier博士将获得以下方面的专业知识：进行空间流行病学分析、使用国家健康信息数据集、改进暴露评估的新方法，以及更好地了解暴露于细颗粒镍对健康的影响。 陈龙志博士将担任主要导师，并监督候选人向独立研究人员过渡的所有方面。此外，一个由3名共同导师组成的团队将为候选人提供互补的研究方法，这将极大地增强和多样化候选人的研究技能。导师团队共同承诺引导候选人扩大研究兴趣和方法，并确保成功过渡到独立研究人员。 在该奖项的独立阶段(R00)，候选人将对心血管疾病的小鼠模型进行一系列体内暴露研究。各种燃烧排放的气溶胶，包括用细颗粒镍增强，并经过不同程度的光化学处理，将被用来解决与暴露于细颗粒气溶胶有关的健康后果。这项工作将导致更好地从机制上了解与细颗粒物暴露相关的氧化应激，特别是镍和有机碳气溶胶，并将导致体内暴露与更广泛规模的流行病学监测举措更好地结合起来。

DESCRIPTION (provided by applicant) Dr. Richard Peltier's long term career goal is to become an independent investigator capable of leading advanced aerosol exposure assessment research that makes a purposeful contribution to understanding exposures and their specific health effects. During the mentored research phase (K99), Dr. Peltier will gain expertise in conducting spatial epidemiological analyses, working with national health information datasets, refining novel approaches to exposure assessment, and developing a better understanding of the health implications associated with exposure to fine particle nickel. Dr. Lung Chi Chen will serve as the primary mentor and oversee all aspects of the candidate's transition to an independent researcher. In addition, a team of 3 co-mentors will provide the candidate with complementary research approaches which will greatly enhance and diversify the candidate's research skill set. Together, the team of mentors has pledged to guide the candidate to extend his research interests and approaches, and to ensure a successful transition to an independent researcher. During the independent phase (R00) of this award, the candidate will conduct a series of in-vivo exposure studies on a murine model of cardiovascular disease. A variety of combustion emissions aerosol, which include enhancements with fine particle nickel, and processed by varying degrees of photochemistry, will be used to address health outcomes associated with exposure to fine particle aerosol. This work will lead to a better mechanistic understanding, with a particular focus on nickel and organic carbon aerosol, of the oxidative stress associated with fine particle exposures, and will lead to a better coupling of in-vivo exposure and broader scale epidemiological surveillance initiatives.