ADMINISTRATIVE

行政核心(核心A)将协调科学活动以及财务管理。 五个项目、两个额外核心和一个分包合同(项目2)的活动和资源 制定本计划。它还将促进个人和个人的日常运营和长期规划 整体科学计划。行政核心的具体目标有三个方面。首先， 行政核心是管理8个分包合同的财务责任，包括预算编制、 管理和审查，并帮助准备非竞争性和竞争性续签，如 以及IACUC和1KB协议批准文件。第二，行政核心将促进 沟通和组织项目负责人会议；因为项目负责人来自五个国家 对于机构而言，解决标准化的、有计划的项目领导会议的需要尤为关键 以积极主动的方式。根据我们准备这份申请的经验，我们建议 项目负责人将每两周举行一次电话会议，并每半年举行一次面对面的会议。这个级别的 互动将足以使个别项目和核心报告进展情况并讨论替代方案 及时采取行动。此外，建议的受密码保护的PPG共享组文件夹 实现新数据和其他相关信息的快速交换和可访问存储。服务器- 托管存储还将绕过文件大小限制和电子邮件带来的相关不便 数据交换。第三，行政核心将协助分享PPG产生的研究与 普通科学界和非科学界。AIM 3有两个组成部分。3.1：“协助组织 一年一度的科学研讨会，与咨询委员会会议同时举行。 将在五年提案期间在五个参与机构之间轮换。演讲者在 研讨会将包括外部咨询委员会成员，以及项目负责人和其他主要负责人 这一领域的科学家。目标3.2：“开发和维护PPG网站”。座谈会和网站 将有助于促进与国内机构调查人员的互动环境，促进互动 在项目领导、咨询委员会和其他特邀演讲者中，并为 向更大的科学界报告PPG正在进行的进展。总而言之，这些行政管理 责任和活动将有助于确保该计划项目的成功。

The Administrative Core (Core A) will coordinate scientific activities as well as management of financial activities and resources for the five projects, two additional cores and a sub-contract (Project 2) that constitute the Program. It will also facilitate daily operations and long-term planning for the individual and overall scientific programs. The specific aims of the Administrative Core are three-fold. First, the Administrative Core is to manage fiscal responsibilities for 8 subcontracts, including budget preparation, management and reviews and to help in the preparation of non-competitive and competitive renewals, as well as document IACUC and 1KB protocol approvals. Second, the Administrative Core will facilitate communication and organize meetings of the Project Leaders; since the Project Leaders are from five institutions, it is particularly critical to address the need for standardized, scheduled Project Leader meetings in a pro-active manner. Based upon our experience in preparing this application, we propose that the Project Leaders will have biweekly phone conferences, and semi-annual face-to-face meetings. This level of interaction will be sufficient to allow individual projects and cores to report progress and discuss alternative approaches in a timely fashion. In addition, the proposed password-protected PPG Shared Groups folder enables fast exchange and accessible storage of new data and other pertinent information. The server- hosted storage will also circumvent file size limitations and related inconveniences imposed by email exchange of data. Third, the Administrative Core will assist in the sharing PPG generated research with the general scientific and lay community. Aim 3 has two components. 3.1: "Assist in the organization of the yearly scientific symposium, which coincides with the Advisory Board meeting." The site of this symposium will rotate among the five participating institutions over the course of the five year proposal. Speakers at the symposia will include members of the External Advisory Board, along with Project Leaders and other leading scientists in the field. Aim 3.2: "To develop and maintain a PPG website". Both the symposia and the website will help to foster an interactive environment with investigators at the home institutions, promote interactions among the project leaders, advisory committee, and other invited speakers, and provide a national forum for reporting ongoing progress by the PPG to the greater scientific community. Together, these administrative responsibilities and activities will help to ensure the success of this program project.