High Performance CMOS Based X-Ray Detector for C-AM CT Imaging

描述（由申请人提供）：图像引导微创治疗可以快速、有效、低失血。但这在很大程度上取决于成像系统。c臂CT成像为术中导航和评估提供传统的二维（2D）和三维体积成像。然而，这些基于平板探测器（FPD）的系统需要在空间分辨率、视场（FOV）、帧率和图像噪声之间进行权衡。一种新型的探测器与碘化汞涂层互补金属氧化物半导体（CMOS）芯片有望解决这些问题。它将允许120微米像素的大视场成像，速度为120帧/秒，噪声仅为500e rms。该方案旨在优化其设计和性能，用于Carm CT成像。这在中风治疗中特别有用。CMOS探测器的阶段性发展将涉及成像链的理论建模，以预测其性能。我们的合作者准备的面板的成像特性将在桌面CT系统上进行测试，并与这些预测进行比较。任何图像退化过程将被识别，检测器的设计将被修改。将检查和优化由平铺芯片（10.5cm × 11cm和22cmx28cm）构建的成像面积增加的面板。将考虑透视、血管造影和灌注CT成像，并与FPD的性能进行比较。将评估减少剂量的机会。最终，两个22cmx28cm的探测器将安装在双翼c臂龙门上。将对犬脑卒中模型闭塞前后的血流和灌注进行体内成像，并与临床CT扫描结果进行比较。将开发一种利用探测器最大潜力的成像方案。该提案的技术创新在于能够使用这种独特的大面积高速检测器来提取最大的2D，特别是3D信息，以辅助微创手术。

DESCRIPTION (provided by applicant): Image guided minimally invasive therapies allow rapid and effective treatments with low blood loss. But it depends heavily on the imaging system. C-arm CT imaging provides conventional two dimensional (2D) and 3D volumetric imaging for intra-procedural navigation and assessment. These systems, based on flat panel detectors (FPD) however, impose trade-offs between spatial resolution, field of view (FOV), frame rate, and image noise. A novel detector with a mercuric iodide coated Complimentary Metal Oxide Semiconductor (CMOS) chip is expected to address these problems. It will allow large FOV imaging with 120 micron pixels at 120 frames/s and only 500e rms noise. The proposal aims to optimize its design and performance for Carm CT imaging. This will be particularly useful in stroke treatment. The staged development of the CMOS detector will involve theoretical modeling of the imaging chain to predict its performance. The imaging characteristics of panels prepared by our collaborator will be tested on a table-top CT system and compared with these predictions. Any image degradation processes will be identified and the detector design will be modified. Panels with increasing imaging area built from tiled chips (10.5cmx11cm and 22cmx28cm) will be examined and optimized. Fluoroscopic, angographic and perfusion CT imaging will be considered and compared with the performance of an FPD. Opportunities for reduction in dose will be evaluated. Eventually two 22cmx28cm detectors will be implemented on a biplane C-arm gantry. In vivo imaging of flow and perfusion pre and post occlusion in a canine stroke model will be conducted and compared with results from a clinical CT scan. An imaging protocol that utilizes the maximum potential of the detector will be developed. The technical innovations of the proposal lie in the ability to use this unique large area high speed detector for extracting maximum 2D, and particularly, 3D information for aiding minimally invasive procedures. RELEVANCE OF RESEARCH: This proposal aims to improve image guided interventions which are growing in importance since they allow quicker reovery and reduce costs compared to conventional surgeries. This will be achieved by developing a camera for x-ray detection that will allow CATscan-like imaging along with viewing in realtime the manipulation of insturments in the brain for stroke treatment.