Mouse Immunopathology

描述(由申请人提供)：申请人寻求支持职业生涯中期的研究人员，利用比较病理学方法进行密集的小鼠免疫病理学研究，并指导小鼠病理生物学研究的初级研究人员。陈柳医生是一名获得委员会认证的外科病理学家。他是副教授，胃肠道和肝脏病理服务主任，以及胃肠道/肝脏病理奖学金培训项目主任。刘博士积极从事临床患者护理、使用小鼠模型的基础和转化性研究，并指导临床研究员、住院医生、博士后研究员、研究生和本科生。刘博士的主要研究重点是丙型肝炎病毒感染的免疫病理学，该项目目前由NIH拨款支持。他的团队已经建立了新的小鼠模型来研究病毒感染的免疫反应。在这项建议中，他将研究丙型肝炎病毒感染中T细胞的反应和调节性T细胞的功能。他将测试新的策略，以利用针对丙型肝炎病毒感染的免疫反应。刘博士的研究小组由非常有才华的年轻博士后研究员、研究生、住院医生/跟随者、医学生和本科生组成。其目标是指导初学者成为未来在老鼠和人类免疫病理学方面都有专长的研究人员。此外，刘博士还在MICE方面建立了国际合作 免疫病理学研究。通过这些研究，刘博士确立了自己在 比较小鼠免疫病理学。在过去的8年里，刘博士与人合著了63篇同行评议文章和9个章节/书评。在该研究所内，刘博士是一位在人类和老鼠系统方面都有专长的知名病理学家。他参与了利用小鼠模型研究自身免疫性疾病的项目。由于这些广泛的正在进行的研究活动，刘博士打算专门花时间培训新的研究人员，以满足在生物医学研究方面对小鼠病理学家日益增长的需求。佛罗里达大学拥有一个综合的动物护理设施，占地169,026平方英尺，容纳了350多个品系的小鼠和1,400个经批准的研究方案。通过与当地和全国的更多合作，该机构将为刘博士的职业发展和指导下一代小鼠病理生物学家提供一个出色的环境。K26职业生涯中期奖是支持刘博士实现这一目标的极好机制。

DESCRIPTION (provided by applicant): The applicant seeks support for a midcareer investigator to conduct intensive mouse immunopathology research using comparative pathology approach and to mentor beginning investigators in mouse pathbiology research. Dr. Chen Liu is a board-certified surgical pathologist. He is an Associate Professor, the Director of Gastrointestinal and Liver Pathology Service, and the Director of GI/Liver Pathology Fellowship training program. Dr. Liu is actively engaged in clinical patient care, basic and translational research using mouse models, and mentoring clinical fellows, residents, postdoctoral fellows, graduate students, and undergraduate students. Dr. Liu's primary research focus is immunopathology of hepatitis C viral infection, which is currently supported by NIH grants. His team has established novel mouse models to investigate immune responses in viral infection. In this proposal, he will study the T cell response and the function of regulatory T cells in HCV infection. He will test novel strategies to harness the immune response against HCV infection. Dr. Liu's research group consists of very talented young postdoctoral research fellows, graduate students, residents/follows, medical student, and undergraduate student. The goal is to mentor beginning investigators to become future investigators who have the expertise in both mouse and human immunopathology. In addition, Dr. Liu has established international collaborations on mouse immuopathology research. Through these studies, Dr. Liu has established himself as an expert in comparative mouse immunopathology. Over the past 8 years, Dr. Liu has co-authored 63 peer-reviewed articles and 9 book chapters/reviews. Within the Institution, Dr. Liu is a well-established pathologist who has expertise in both human and mouse systems. He is involved in research projects on autoimmune diseases using mouse models. Because of these extensive ongoing research activities, Dr. Liu intends to have dedicated time to train new investigators who will fill the growing need of mouse pathologist in biomedical research. The University of Florida has a comprehensive animal care facility with 169,026 square feet of space that hosts more than 350 strains of mice and 1,400 approved research protocols. With additional collaborations locally and nationally, the institution will provide an outstanding environment for Dr. Liu's career development and mentoring next generation of mouse pathobiologists. The K26 midcareer award is an excellent mechanism to support Dr. Liu to achieve this goal.