Developing MBSR for Application in Alcoholism Treatment

描述（由申请人提供）：在酒精依赖个体开始戒酒后，饮酒复发是常见的结果。这种复发主要发生在涉及个人或人际压力的情况下。作为回应，目前的申请（在NIAAA的“行为和综合治疗发展计划”项目公告{PA06-486}下提交）建议在酒精中毒治疗中采用、应用和评估基于正念的减压（MBSR），这是一种完善的减压干预措施。正念减压法强调对意识内容的超然观察和意识的发展，已被证明在提高应对压力的能力、增强应对能力和心理健康方面是有效的。然而，文献中没有对照临床研究评估正念减压疗法对酒精依赖者的独特效果。该项目将分两个阶段进行。在第一阶段（1a阶段活动）中，针对酒精依赖男性和女性的10期常规治疗（TAU），将采用8期小组正念减压治疗手册进行调整。在II期（1b期活动），将进行一项试点临床试验，以检查将MBSR添加到TAU中对酒精依赖门诊患者的影响。参与TAU + MBSR的患者的结果将与接受TAU +一系列健康和生活方式讲座（TAU + HLL）的患者的结果进行比较。本研究的积极发现将为更大规模的二期对照临床试验奠定基础，以进一步评估正念减压疗法在酒精中毒治疗中的作用，并确定其作用机制

DESCRIPTION (provided by applicant): Relapses to drinking are common outcomes following the initiation of abstinence among alcohol dependent individuals. Such relapses predominantly occur in situations involving either intrapersonal or interpersonal stress. In response, the present application (submitted under NIAAA's "Behavioral and Integrative Treatment Development Program" Program Announcement {PA06-486}) proposes the adaptation, application, and evaluation of Mindfulness-based Stress Reduction (MBSR), a well-established stress reduction intervention, in alcoholism treatment. MBSR, with its emphasis on the development of detached observation and awareness of the contents of consciousness, has been shown to be efficacious in increasing the ability to cope with stress and in enhancing coping and psychological well-being. However, there are no controlled clinical studies in the literature evaluating the unique effects of MBSR among persons with alcohol dependence. The project will be conducted in two phases. In Phase I (Stage 1a activity), an 8- session treatment manual for conducting group-based MBSR will be adapted for use in the context of a standardized 10-session treatment-as-usual (TAU) for alcohol dependent men and women. In Phase II (Stage 1b activity), a pilot clinical trial will be conducted to examine the effects of adding MBSR to TAU for alcohol dependent outpatients. The outcomes of patients participating in TAU + MBSR will be compared to the outcomes for patients receiving TAU plus a series of Health and Lifestyle Lectures (TAU + HLL). Positive findings emerging from this research will serve as foundation for a larger, Stage 2 controlled clinical trial to further evaluate MBSR in alcoholism treatment and to determine the mechanisms of action by which MBSR may operate to effect such benefits. The long-term goal of this research is to decrease relapse to drinking following treatment, which will provide significant health benefits to persons being treated for alcohol dependence.