Administrative Core

CEBASM的生物行为模型扩展了P20中心在以下方面的工作： 生物和行为现象，通过关注生物行为临床科学的进步 通过与复杂星座的生物行为机制、管理和结果相关的研究， 包括常见的疲劳症状。生物行为研究的重点是 生物、行为和社会因素之间的相互作用及其对结果的影响\一般模型 图2所示的方法已经被各个项目主管用作基础框架， 检查疲劳和相关的生物行为现象，具体到他们所反对的项目。具体目标 的中心项目包括生物行为科学的研究，具体到理解和管理 疲劳和相关症状星座及其对生物行为健康结果的影响 不同的人群。 作为CEBASM的指导概念框架，扩展模型代表了 生物和行为变量的相互作用，以及在一个关键的健康背景下的关键辅因子 体验.关键的健康体验涉及健康状况的急剧变化或对健康状况变化的感知。 与健康的关系，使个人处于危险之中。症状体验表现为社会心理和 行为调节剂（包括生物行为症状管理干预）与生物学相互作用 调解员在生物学领域，中心的研究重点是 神经内分泌和免疫介质，可能是症状群的基础。这些复杂 在一个关键的健康经验的背景下的相互作用被认为是解释，至少部分，通常 发生的症状，如疲劳和心理困扰，并最终，生物行为的结果， 社会心理功能、生活质量和身体健康领域。此外，许多主持人， 包括个人因素、已知和未知的混杂变量以及间接协变量， 症状体验和生物行为健康结果。

The biobehavioral model for the CEBASM expands the work of the P20 Center on interactions among biological and behavioral phenomena by focusing on the advancement of biobehavioral clinical science through research related to biobehavioral mechanisms, management, and outcomes of complex constellations of symptoms, including the commonly occurring symptom of fatigue. Biobehavioral research focuses on the interactions among biological, behavioral, and social factors and their effects on outcomes\ The general model depicted in Figure 2 has been used by the individual Project Directors as a foundational framework for examining fatigue and associated biobehavioral phenomena specific to their pi^oposed projects. Specific aims of Center Projects include investigation of biobehavioral science specific to understanding and managing fatigue and associated symptom constellations and their impacts on biobehavioral health outcomes across diverse populations. Serving as the guiding conceptual framework for the CEBASM, the expanded model represents the interaction of biological and behavioral variables as well as critical cofactors in the context of a crifical health experience. A critical health experience involves a dramatic change in health or a perception of change in relation to health that places an individual at risk. The symptom experience unfolds as psychosocial and behavioral moderators (including biobehavioral symptom management interventions) interact with biological mediators. In the biological domain Center research focuses on the multidimensional interactions among neuroendocrine and immunological mediators that may underiie symptom constellafions. These complex interactions in the context of a crifical health experience are thought to explain, at least in part, commonly occurring symptoms such as fatigue and psychological distress and, ultimately, biobehavioral outcomes in the domains of psychosocial functioning, quality of life, and physical health. Additionally, numerous moderators, including person factors, known and unknown confounding variables, as well as indirect covariates, contribute to symptom experiences and biobehavioral health outcomes.