Injury, Ischemia and Inflammation: A Translational Approach to Trauma Treatment

描述（由申请人提供）：创伤是美国主要的健康和社会问题。我们提出的博士后培训计划满足了创伤研究的严重国家需求，旨在开发和评估新的监测策略，基于民用和军事创伤的临床相关实验室模型中的目标的复苏，免疫调节和止血的新方法，可以帮助将实验室结果转化为床边。这个创伤博士后培训计划致力于将新的想法从台式机翻译到床边。每位学员将完成为期2年的研究金和临床研究科学硕士学位，共有10名学员在5年的项目期内完成该计划。培训计划将得到德克萨斯州圣安东尼奥创伤研究所（TRISAT）成员机构的支持;该市三个一级创伤中心和美国陆军外科研究所（USAISR）的临床合作，USAISR是国防部（DOD）专门致力于改善战斗伤员护理的独特研究实验室。UTHSCSA外科部和TRISAT财团是唯一有资格填补现有培训缺口的机构，原因有三。首先，TRISAT联盟为大量患者群体（每年超过8，000例创伤病例）提供物理资源和高素质和敬业的外科医生，科学家和其他专家，他们跨越与创伤和重症监护相关的广泛主题。其次，TRISAT创伤医院与UTHSCSA合作，帮助改善战场准备和创伤战斗外科护理的结果。第三，UTHSCSA在与损伤，缺血和炎症相关的其他领域（包括传染病，肿瘤学，成像，牙科和衰老）的转化研究方面有着悠久而成功的历史，这些学科的几位研究人员致力于指导博士后学员在他们的基础和临床实验室。UTHSCSA外科部门已承诺培训所有居民在转化研究两年（以下第二年的居住），以及要求所有居民完成科学的临床研究硕士学位。如果我们要改善结果并降低创伤死亡率，我们必须在重症监护和创伤研究方面拥有训练有素的医生科学家骨干。填补目前的国家培训缺口尤为重要，因为创伤是美国的主要健康和社会问题。事实上，创伤超过了癌症和心脏病造成的生命损失，在美国每年造成的损失超过2600亿美元。

DESCRIPTION (provided by applicant): Trauma is a leading health and social issue in the United States. Our proposed postdoctoral training program fulfills a serious national need in trauma research, with aims to develop and evaluate new monitoring strategies, novel methods of resuscitation, immunomodulation and hemostasis based on targets in clinically-relevant laboratory models of civilian and military trauma that can help translate the laboratory findings to the bedside. This postdoctoral training program in trauma is dedicated to translating new ideas from bench top to bedside. Each trainee will complete a 2-year fellowship and a Master's of Science in Clinical Investigation with a total of 10 trainees completing the program over the 5- year project period. The training program will be supported by the Trauma Institute of San Antonio, Texas (TRISAT) member institutions; an established congressionally-supported clinical cooperative of the city's three Level I trauma centers and United States Army Institute of Surgical Research (USAISR), a unique research laboratory in the Department of Defense (DOD) dedicated entirely to improving combat casualty care. The UTHSCSA Department of Surgery and the TRISAT consortium are uniquely qualified to fill the existing training gap for three reasons. First, the TRISAT consortium serves a large patient population (more than 8,000 trauma cases per year) with the physical resources and a highly qualified and dedicated staff of surgeons, scientists, and other experts who span a broad spectrum of topics related to trauma and critical care. Second, the TRISAT trauma hospitals work with the UTHSCSA to help improve battlefield readiness and outcome of trauma combat surgical care. Third, the UTHSCSA has had a long, successful history of translational research in other fields related to injury, ischemia and inflammation, including infectious disease, oncology, imaging, dentistry, and aging and several researchers in these disciplines have committed to mentor the postdoctoral trainees in their basic and clinical laboratories. The UTHSCSA Surgery Department has committed to training all residents in translational research for two years (following the second year of residency) as well as requiring that all residents complete the Master's of Science in Clinical Investigation. We must have a well-trained cadre of physician-scientists in critical care and trauma research if we are going to have improved outcomes and reduce mortality from trauma. Filling the current national gap in training is especially important because trauma is a leading health and social issue in the U.S. In fact, trauma exceeds years of life lost from cancer and heart disease combined and results in annual cost of over $260 billion in the United States.