Regulation and biological impact of IL-17 production by gamma delta T cells

项目主任/首席调查员(末位、第一位、中位)：简越秀项目主任/首席调查员(末位、第一位、中位)：简越秀 1 R01 A1080829-O1AI I ROL AI080829-01 A 1 摘要炎症是对组织损伤和/或感染的快速反应。虽然这在很大程度上是一种先天炎症，但它是对组织损伤感染的快速反应。虽然在脊椎动物中，它主要是一种先天反应，但在脊椎动物中，它已经进化到需要T细胞因子IL-17，它已经进化到需要T细胞细胞因子，以促进中性粒细胞和单核细胞在骨髓中的扩张，并将它们释放和重新聚集到炎症部位。这一过程加强了炎症级联到部位的炎症。这个过程加强了炎症级联信号，根除了有害信号，启动了解决方案，并启动了适应性免疫 (U) =w‘ 回应。我们以前的实验表明，El EIIT细胞唯一适合安装一个实验表明，0 I；J T细胞是唯一适合安装反应。IL-17在急性炎症开始时的反应，我们发现E1II1J细胞是急性炎症的主要ILonset，我们发现DCTr细胞在CFA免疫开始时是IL-17+细胞。虽然IL-I 7f LIT细胞的发展对IL-17：TDI；J T细胞17+群体在DI中的调节有免疫作用，但对IL-17是如何在[ILIT细胞]中调节的却知之甚少。此外，对LIT的反应已被记录在案，尽管李L有缺陷；JT反应在缺乏DI；JT细胞的小鼠中已被注意到，缺乏LI1T细胞的可能性，这些细胞在炎症反应中早期作用影响启动过程的可能性尚未被探索。我们将调查这些领域，这些领域对于理解所探讨的问题具有至关重要的意义。意志区域，这是了解宿主免疫防御的基础。防守。 -，Q“ .2) =-0 0 支付 .L.， E‘6 --6 ，茶 0-0 小野

Program Director/Principallnvestigator (Last, First, Middle): Chien, Yueh-Hsiu Program Director/Principal Investigator (Last, First, Middle): Chien, Yueh-Hsiu 1 R01 A1080829-O1AI I ROl AI080829-01 A 1 ABSTRACT Inflammation is a rapid response to tissue damage and/or infection. While it is largely an innate Inflammation a rapid response to tissue damage infection. While is largely an innate response during its initial stages, in vertebrates, it has evolved to require a T ceU cytokine, IL-17, in it has evolved to require a T cell cytokine, to promote the expansion of neutrophils and monocytes in the bone marrow and their release and recruitment to sites of inflammation. This process strengthens the inflammatory cascade to to sites inflammation. This process strengthens the inflammatory cascade to signal, eradicate the injurious signal, starts the resolution program and launches the adaptive immune (U) =w' response. Our previous experiments suggested that El EIIT cellsare uniquely suited to mount an experiments suggested that 0 I;J T cells are uniquely suited to mount an response. IL-17 response at the onset of acute inflammation and we found that E1II1J cells are the major ILonset of acute inflammation and we found that DCTr cells are the IL IL-17 17+ population at the onset of CFA immunization.. While the development of IL-i 7f Li LIT cells has immunization the development of IL-17:tDI;J T cells 17+ population regulated in DI;:JT been well documented, little is known about how IL-17 is regulated in[ILIT cells. Furthermore, documented, deficier)to LiT responses have been noted in although deficientLi l;JT responses have been noted in mice lackingD I;JT cells, the possibility lacking LI1T cells, the possibility thqtthese cells act early in an inflammatory response to affect the priming process has not been in thatthese priming been explored. We will investigate these areas, which are of fundamental importance in understanding explored. will areas, which fundamental in understanding host immune defense. defense. -,Q" .2) =-0 0 pay .L., E'6 --6 ,tea 0-0 ono