Trihalomethane Exposures in NHANES 1999-2001

1999-2001年国家健康和营养调查（NHANES）包括一项关于美国成年人暴露于三卤甲烷（THMs）、水消毒的有毒和致癌副产品的身体负担和主要预测因素的特别调查。NHANES血液测量显示了人口广泛暴露的证据，单个THMs的检测频率为79- 98%。这是一个全国性的公共卫生问题，因为流行病学研究表明，长期暴露于处理过的水（例如，淋浴/洗澡）之间存在关联。游泳和饮用用自来水制成的热饮料）和某些癌症（膀胱癌、结肠直肠癌）以及不良出生结果（早产、小于胎龄儿/宫内生长受限）。我们的长期目标是阐明预测血液THM水平个体间变异的因素。我们的具体目标是使用NHANES 1999-2001年的数据来调查怀孕状态对美国女性的水和血液THM水平之间的关系的影响，并调查摄入常见的CYP 2 E1，GSTT 1，CYPD 6和其他THM代谢酶的诱导剂/抑制剂对美国女性和男性血液THM水平的影响。我们将构建多元线性回归模型来评估这些关系，控制自来水THM浓度。拟议的调查结果可能有助于为制定关于降低易感个体中THM身体负担的建议提供信息。 公共卫生相关性：大多数美国人的血液中都含有可检测水平的三卤甲烷，这是水消毒的有毒和致癌副产品。我们将分析1999-2001年美国国家健康和营养调查中三卤甲烷专项调查的数据，以研究妊娠状态和摄入CYP 2 E1、GSTT 1、CYPD 6和其他异生物质代谢酶的常见诱导剂/抑制剂对血液三卤甲烷水平的影响。拟议的调查结果可能有助于为制定关于降低易感个体中THM身体负担的建议提供信息。

DESCRIPTION (provided by investigator The 1999-2001 National Health and Nutrition Examination Survey (NHANES) included a special investigation on body burdens and major predictors among U.S. adults of exposure to trihalomethanes (THMs), toxic and carcinogenic by-products of water disinfection. The NHANES blood measurements show evidence of widespread exposure in the population, with detection frequencies ranging from 79- 98 percent for individual THMs. This is a national public health concern since epidemiologic studies show associations between long-term exposure to treated water (through, for example, showering/bathing, . swimming, and consuming hot beverages made with tap water) and certain cancers (bladder, colorectal) as well as adverse birth outcomes (preterm delivery, small for gestational age/intrauterine growth restriction). Our long-term goal is to elucidate the factors predicting inter-individual variability in blood THM levels. Our specific aims are to use the NHANES 1999-2001 data to investigate the influence of pregnancy status on the relationship between water and blood THM levels among U.S. women, and to investigate the influence of intake of common inducers/inhibitors of CYP2E1, GSTT1, CYPD6 and other THM-metabolizing enzymes on blood THM levels in U.S. women and men. We will construct multiple linear regression models to evaluate these relationships, controlling for tap water THM concentrations. Results of the proposed investigations could help inform the development of recommendations on lowering THM body burdens among susceptible individuals. PUBLIC HEALTH RELEVANCE: The majority of Americans have detectable levels of trihalomethanes, toxic and carcinogenic by- products of water disinfection, in their blood. We will analyze data from the special trihalomethane investigation of the 1999-2001 U.S. National Health and Nutrition Examination Survey to investigate the influence of pregnancy status and the intake of common inducers/inhibitors of CYP2E1, GSTT1, CYPD6 and other xenobiotic metabolizing enzymes on blood trihalomethane levels. Results of the proposed investigations could help inform the development of recommendations on lowering THM body burdens among susceptible individuals.