9th International Symposium on Bordetella

描述（由申请人提供）： 摘要 PI：CARBONETTI，NICHOLAS H. 项目：1 R13 AI 091296 -01标题：第九届博德特氏菌国际研讨会登录号：3256068 ================== 注意事项：本摘要摘自应用程序，未经SRA验证。当应用程序扫描过程出现问题时，提取的文本可能不正确或不完整。 ================== 1906年，Bordet和Gengou在巴斯德研究所首次培养了百日咳杆菌，这是人类呼吸道疾病百日咳（百日咳）的病原体，2006年在巴黎巴斯德研究所举行的上一次国际百日咳杆菌会议包括庆祝这一重要事件的百年纪念。属的其他重要成员，B.支气管炎，一种也可感染免疫功能低下的人的动物病原体，和B。副百日咳是一种可引起轻度百日咳样疾病的人类病原体，分别于1912年和1938年被分离。尽管积极的免疫计划覆盖面很广，但美国和世界其他地区的百日咳发病率最近一直在上升，2005年美国报告的病例数为50年来的最高水平。除了最初的博德特莱，B。禽流感是鸟类呼吸道感染的重要原因，并造成家禽业的巨大经济损失。此外，还报道了该属内的几个新种，如B.欣兹，B. holmesii，B.吸虫和B. petrii，在疾病谱、毒力因子或发病机理方面没有很好的特征。B的基因组。百日咳，B. B.副百日咳、B. B.支气管败血症B. B. avium和B. petrii已经测序并公布了数据，新的基因组序列信息将在2010年出现。因此，这是一个特别及时的会议，讨论这些和其他重要的问题，在博德特氏菌生物学。该提案要求支持学生和博士后研究员、来自代表性不足的少数群体的受训人员以及发展中国家的科学家参加将于2010年10月在马里兰州巴尔的摩内港万丽万豪酒店举行的第九届博德特氏菌国际研讨会。包括发病机制、免疫学、基因组学、流行病学、预防和治疗。博德特氏菌社区是一个特别开放和协作的科学家集合，重要的是要确保和支持学员参加这样的会议，以鼓励未来的研究人员在这一领域。本提案中要求提供差旅费的会议是对百日咳杆菌和有关杆菌属生物体引起的疾病具有研究、临床、公共卫生和疫苗兴趣和专门知识的人的定期活动。最近，美国的百日咳病例数达到了50年来的最高水平，一种新的疫苗制剂被批准用于青少年和成人。百日咳和相关疾病目前是美国和国际公共卫生的一个重大问题，这些疾病的所有方面都将在这次会议上得到解决。支持受训人员出席和参加会议对于培养这一领域的新调查员至关重要。

DESCRIPTION (provided by applicant): Abstract PI: CARBONETTI, NICHOLAS H. Project: 1R13AI091296-01 Title: 9th International Symposium on Bordetella Accession Number: 3256068 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== Bordetella pertussis, the causative agent of the human respiratory disease pertussis (whooping cough) was cultured for the first time in 1906, by Bordet and Gengou, at the Institut Pasteur, and the previous International Bordetella meeting in 2006 at the Institut Pasteur in Paris included celebration of the centennial of that important event. Other important members of the genus, B. bronchiseptica, an animal pathogen that can also infect immunocompromised humans, and B. parapertussis, a human pathogen that can cause a mild pertussis-like disease, were isolated in 1912 and 1938, respectively. The incidence of pertussis has recently been increasing in the US and other parts of the world, despite active immunization programs with wide coverage, and the number of reported cases in the US in 2005 was a 50-year high. Beyond the original bordetellae, B. avium is an important cause of respiratory infections in birds and is responsible for tremendous economic losses for the poultry industry. In addition, several new species within the genus, such as B. hinzii, B. holmesii, B. trematum and B. petrii, are not well characterized with regard to spectrum of disease, virulence factors or pathogenesis. The genomes for B. pertussis, B. parapertussis, B. bronchiseptica, B. avium and B. petrii have been sequenced and the data published, and new genome sequence information will emerge in 2010. Therefore, this is a particularly timely meeting to discuss these and other important issues in Bordetella biology. This proposal is requesting support for students and post-doctoral fellows, for trainees from underrepresented minority groups and for developing world scientists to attend the 9th International Symposium on Bordetella, to be held in October 2010 at the Renaissance Marriott Hotel at the Inner Harbor, Baltimore, MD. Sessions on Pathogenesis, Immunology, Genomics, Epidemiology, and Prevention and Treatment will be included. The Bordetella community is an especially open and collaborative collection of scientists and it is important to assure and support attendance of trainees at meetings such as this, to encourage future investigators in this field. The meeting for which travel funds are being requested in this proposal is a regular event for those with research, clinical, public health and vaccine interest and expertise in diseases caused by Bordetella pertussis and related organisms in the genus Bordetella. Very recently, the number of pertussis cases in the US was at a 50-year high, and a new vaccine formulation was approved for use in adolescents and adults. Pertussis and related illnesses are currently a significant problem for US and international public health and all aspects of these illnesses will be addressed at this meeting. Support for trainees to attend and participate in the meeting is essential for development of new investigators in this field.