2010 Cell and Molecular Fungal Biology; Gordon Research Conference

描述（由申请人提供）：本提案要求对细胞和分子真菌生物学戈登研究会议将于2010年6月13日至18日在霍洛维茨学校举行的部分支持。会议的广泛和长期目标是在研究人员中传播有关真菌生物学的信息，以增加我们对基础真菌生物学及其在社会重要问题中的应用的集体理解。真菌是优秀的真核生物模式生物，因此会议的大部分内容将是NIH（国家普通医学科学研究所）目标的核心。真菌引起重大的人类疾病;提出的许多研究将解决美国国立卫生研究院过敏和传染病研究所的利益。本次会议的具体目标将是召集52位代表真菌研究前沿的发言人，共约100人。130-140名与会者，其中大多数将提交海报，在一个几乎没有分心的环境中举行为期五天的会议。口头会议和海报会议旨在强调讨论和建立联系，对以往会议的评价表明了这种形式的有效性。2010年会议将联合收割机结合本会议的新主题，例如，系统生物学，小RNA，群体基因组学，具有持久意义的主题，例如，发病机制、共生、膜运输以及细胞骨架和马达。这一应用的重要性在于，本次会议在加速国际真菌生物学界的研究，包括疾病的预防和治疗方面发挥了示范作用。该应用的健康相关性集中在真菌在人类疾病中的作用，包括移植患者的两种最重要的疾病，念珠菌病和曲霉病，以及系统性真菌疾病，球孢子菌病和组织胞浆菌病。该应用的健康相关性涉及真菌在人类疾病中的作用以及真菌在理解真核生物学的基本特征中的作用。真菌生物学的知识是通过阐明真菌发育的基本特征，包括孢子萌发，菌落建立，生长和繁殖来预防真菌疾病的必要条件。这方面的知识也是必不可少的治疗真菌疾病的药物和分子候选人的疫苗确定目标。使用真菌作为模式生物，通过研究基本的细胞和分子过程，继续加速我们对所有复杂生命（包括人类）的基本特征的理解。

DESCRIPTION (provided by applicant): This proposal requests partial support for the Gordon Research Conference on Cellular and Molecular Fungal Biology to be held at the Holderness School, June 13-18, 2010. The broad and long-term goal of the conference is to spread information about fungal biology among researchers to increase our collective understanding of basic fungal biology and its application to socially important problems. Fungi are excellent eukaryotic model organisms, so much of the conference will be central to the aims of NIH- National Institute of General Medical Science. Fungi cause significant human disease; so much of the research presented will address the interests of the NIH-National Institute of Allergy and Infectious Disease. The specific aim of this meeting will be to convene 52 speakers who represent the leading edge of fungal research with a total of ca. 130- 140 participants, most of whom will present posters, for a five-day conference in a setting with few distractions. The oral and poster sessions are designed to emphasize discussion and networking, and evaluations from past conferences demonstrate the effectiveness of this format. The 2010 meeting will combine topics new to this conference, e.g., systems biology, small RNA, population genomics, with topics of enduring significance, e.g., pathogenesis, symbiosis, membrane trafficking, and cytoskeleton and motors. The significance of this application is the demonstrated effect of this conference in accelerating research in the international fungal biology community, including prevention and treatment of disease. The health relatedness of this application centers on the role of fungi in human disease, including two of the most important diseases of transplant patients, candidiasis and aspergillosis, and the systemic fungal diseases, coccidioidomycosis and histoplasmosis. The health relatedness of this application concerns both the role that fungi play in human disease and the role that fungi play in understanding the fundamental features of eukaryotic biology. Knowledge of the biology of fungi is essential to the prevention of fungal disease by illuminating basic features of fungal development, including spore germination, colony establishment, growth, and reproduction. This knowledge is also essential to treatment of fungal disease by identifying targets for pharmaceuticals and molecular candidates for vaccines. Use of fungi as model organisms continues to speed our understanding of basic features of all complex life, including humans, through study of basic cellular and molecular processes.