Enzymology and Molecular Biology of Carbonyl Metabolism XV

描述(申请人提供)：本R13提案的目的是申请资助研究生和博士后参加一个名为“羰基代谢的酶学和分子生物学”的国际会议。这将是申请人组织的第十五次会议，将于2010年7月6日至10日在肯塔基州列克星敦举行。会议讨论的三个酶家族是醇脱氢酶、乙醛脱氢酶和羰基还原酶。主题从酶的生理作用到它们参与细胞事件。讨论了酶的作用机制和基因调控，以及酶在药物代谢和解毒反应中的作用。研究生和博士后总是参加会议，偶尔也有本科生参加，他们展示海报，资深科学家被邀请做口头报告。所有人都被邀请提交一份手稿，在一本期刊的特别版上发表。不需要资金来支持资深科学家，因为他们每个人都必须支付自己的费用。由于难以获得研究支持，人们担心许多实验室将无法像过去那样派遣合格的学生参加会议。通常有25名学生和50-60名资深科学家一起参加了会议。如果有津贴，学生将能够参加这次会议，在那里学生和资深科学家自由互动，并且在过去形成了许多合作，并获得了未来的博士后职位。 与公共卫生相关：“羰基”会议是唯一专门讨论这一主题的会议，大多数研究羰基代谢的生理和酶学重要性的主要科学家都出席了会议。这些酶参与生物转化、药物和异体代谢。该提案的目的是获得资金，以支持研究生和博士后参加这次国际会议。

DESCRIPTION (provided by applicant): The purpose of this R13 proposal is a requests funds for graduate and post doctoral students to attend an international meeting called Enzymology and Molecular Biology of Carbonyl Metabolism. This will be the fifteenth meeting the applicant has organized and it will be held in Lexington, Kentucky July 6-10, 2010. The three enzyme families discussed at the meeting are alcohol dehydrogenase, aldehyde dehydrogenase and carbonyl reductase. The topics range from the physiological role of the enzymes to their involvement in cellular events. Enzyme mechanism and gene regulation are discussed as well as the role of the enzymes in drug metabolism and detoxification reactions. Graduate and post doctoral students have always attended the meeting, as has an occasional undergraduate student, where they present posters while senior scientists are invited to make oral presentations. All are invited to submit a manuscript for publication in a special edition of a journal. No funds are requested to support senior scientist as each of them have to pay their own way. Because of the difficulty in securing research support it is feared that many laboratories will not be able to send qualified students to the meeting as they have in the past. Typically 25 students have attended the meeting along with 50-60 senior scientists. If stipends are available students will be able to attend this meeting where students and senior scientists interact freely and, in the past, formed many collaborations and secured future post doctoral positions. PUBLIC HEALTH RELEVANCE: The "Carbonyl" meeting is the only meeting devoted to this topic and most of the major scientists investigating the physiological and enzymological importance of carbonyl metabolism attend the meeting. The enzymes are involved in biotransformations, drug and xenobiotic metabolism. The purpose of the proposal is to obtain funds to support graduate and post doctoral student participation at this international meeting.