Brucellosis Research Conference 2009

描述（申请人提供）：布鲁氏菌病是世界上最常见的人畜共患疾病之一。这种疾病是由布鲁氏菌属的成员引起的，这是革兰氏阴性的兼性细胞内细菌。在家养和野生哺乳动物中，布鲁氏菌病常常导致流产和不孕。在人类中，布鲁氏菌病表现为一种慢性感染，伴有波状热和全身不适；其他临床症状因受影响的器官系统而异。众所周知，人类布鲁氏菌病很难用抗生素治疗，需要长期的多种抗生素治疗方案，即使在抗生素治疗之后，复发率也可能超过10%。目前没有针对人类布鲁氏菌病的疫苗。拟议的布鲁氏菌病研究会议（BRC）的主要目标是为布鲁氏菌病研究人员，包括年轻研究人员和学员，提供一个机会，在有利于交流思想和建立合作的环境中介绍和讨论他们的最新研究成果。会议将特别强调促进年轻研究人员的参与，如研究生和博士后，从而促进这些研究人员与知名研究人员的互动。会议将于2009年12月5日至6日在伊利诺伊州芝加哥市的万豪酒店举行，为期两天。预计将有来自美国和其他几个国家的120至150名与会者参加此次会议。本次会议汇集了来自兽医、医学、流行病学和基础微生物学学科的科学家，这些学科不仅从受感染的人的角度，而且从动物宿主和疾病生态的角度，对解决人畜共患疾病问题至关重要。

DESCRIPTION (provided by applicant): Brucellosis is one of the most common zoonotic diseases worldwide. The disease is caused by the members of the genus Brucella, which are Gram-negative, facultatively intracellular bacteria. In domestic and wild mammals brucellosis often results in abortions and infertility. In humans, brucellosis manifests itself as a chronic infection with undulant fever and general malaise; other clinical signs vary depending on the affected organ systems. Human brucellosis is notoriously difficult to treat with antibiotics, requiring a prolonged multiple antibiotic regimen, and relapse rates can be over 10%, even after the antibiotic treatment. At present there is no vaccine available for human brucellosis. The main objective of the proposed Brucellosis Research Conference (BRC) is to provide an opportunity for brucellosis researchers, including young investigators and trainees, to present and discuss their latest research findings in an environment that is conducive to the exchange of ideas and provides the opportunity for establishing collaborations. Special emphasis will be given to promoting the participation of young researchers such as graduate students and postdoctoral fellows in the conference, thereby facilitating the interactions of these researchers with well-established investigators. The conference will be held for two days, Dec. 5-6, 2009, at Marriott Downtown Magnificent Mile hotel, Chicago, IL. It is anticipated that between 120 and 150 participants from the United States and several other countries will attend this conference. This conference brings scientists from veterinary, medical, epidemiological and basic microbiology disciplines that are crucial to address the issue of zoonotic disease from the viewpoint not only of the infected human, but also of the animal reservoir and the ecology of the disease.